P9 Repeatability and Predictors of a Potentially Blood Pressure-Independent Parameter of Arterial Stiffness

Mark Butlin; James Cox; Bart Spronck; Isabella Tan; Alberto Avolio

doi:10.2991/artres.k.191224.044

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Volume 25, Issue Supplement 1, December 2019, Pages S51 - S51

P9 Repeatability and Predictors of a Potentially Blood Pressure-Independent Parameter of Arterial Stiffness

Authors

Mark Butlin¹, James Cox¹, Bart Spronck², Isabella Tan¹, Alberto Avolio³^{, *}

¹Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia

²School of Engineering and Applied Science, Yale University, New Haven, CT, USA

³Macquarie University, Sydney, Australia

^*Corresponding author. Email: alberto.avolio@mq.edu.au

Corresponding Author

Alberto Avolio

Available Online 15 February 2020.

DOI: 10.2991/artres.k.191224.044 How to use a DOI?
Abstract: Background: Arterial stiffness (e.g., as measured by carotid-femoral pulse wave velocity (cfPWV)) changes acutely with blood pressure (BP). High cfPWV at high BP could be due to structural arterial changes or acute BP effects. Various parameters have been proposed as BP-independent parameters of arterial stiffness. These rely on assumptions to simplify theoretical calculations. This study evaluates a parameter quantifying BP dependency of cfPWV through BP manipulation, avoiding assumptions and mathematical derivations.

Methods: Brachial BP and cfPWV (SphygmoCor XCEL, AtCor Medical, Australia) were assessed in seated and supine position. The postural change invokes a systemic and hydrostatic BP change, thus changing cfPWV. ΔcfPWV/ΔBP was calculated. Repeatability was assessed in 25 participants (28 ± 11 years (mean ± SD), 52% female) across two visits on separate days. Cross-sectional correlation with age, gender, height, weight, seated BP, and supine cfPWV was assessed by stepwise linear regression across 135 participants (49 ± 23 years, 48% female).

Results: Mean ΔcfPWV/ΔBP was 0.061 ± 0.025 m/s/mmHg. Repeatability showed a between-measurement difference of 0.005 ± 0.028 m/s/mmHg (8.2% error on mean). ΔcfPWV/ΔBP was cross-sectionally correlated with seated diastolic BP (standardised β = –0.506, p < 0.001), systolic BP (β = 0.503, p < 0.001), weight (β = –0.220, p = 0.006), and heart rate (β = 0.178, p = 0.039) (model p < 0.05, r² = 0.264).

Conclusion: ΔcfPWV/ΔBP showed fair repeatability. Notwithstanding accounting for BP, it correlated with typical long-term modifiers of arterial stiffness such as chronic elevated BP and weight. Further studies are required to validate if dividing ΔcfPWV by ΔBP, following acute intervention, creates an acceptable BP-independent arterial stiffness variable before the parameter is investigated for cardiovascular risk prediction to evaluate its clinical utility.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal: Artery Research
Volume-Issue: 25 - Supplement 1
Pages: S51 - S51
Publication Date: 2020/02/15
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.191224.044 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Mark Butlin
AU  - James Cox
AU  - Bart Spronck
AU  - Isabella Tan
AU  - Alberto Avolio
PY  - 2020
DA  - 2020/02/15
TI  - P9 Repeatability and Predictors of a Potentially Blood Pressure-Independent Parameter of Arterial Stiffness
JO  - Artery Research
SP  - S51
EP  - S51
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.044
DO  - 10.2991/artres.k.191224.044
ID  - Butlin2020
ER  -

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