Artery Research

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Volume 25, Issue Supplement 1, December 2019, Pages S3 - S3

1.4 Prognostic Relevance of Augmentation Index in Prevalent Cardiovascular Disease and Total Mortality: Data From the General Population

Authors
Natalie Arnold1, *, Tommaso Gori1, Anika Gündling1, Andreas Schulz1, Jürgen H. Prochaska1, Marina Panova-Noeva1, Irene M. Schmidtmann1, Norbert Pfeiffer1, Manfred Beutel1, Karl J. Lackner2, Thomas Münzel2, Philipp S Wild1
1University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
2Institute for Clinical Chemistry and Laboratory Medicine of the Johannes Gutenberg-University Mainz, Mainz, Germany
*Corresponding author. Email: natalie.arnold@unimedizin-mainz.de
Corresponding Author
Natalie Arnold
Available Online 15 February 2020.
DOI
10.2991/artres.k.191224.003How to use a DOI?
Abstract

Objectives: To investigate the role of peripheral augmentation index (AIx) for the prediction of prevalent cardiovascular disease (CVD) and total mortality in the general population in age- and sex- specific manner.

Methods: AIx was measured in 11,250 participants of the population-based Gutenberg Health Study by Endo-PAT device. For analysis, the study population was stratified by age and sex (men: <60/≥60 years; women: <55/≥55 years), since a non-linear increase in AIx with aging with a plateau-building at age of 55 years in women and at 60 years in men was observed.

Results: During the 8-yrs follow-up, a total of 584 deaths (382 men/202 women) occurred. In males, top tertile (T) of AIx was associated with all-cause mortality (hazard ratio (HR) in younger men was 2.30 (95% CI 1.41–3.76) and 1.42 (95% CI 1.09–1.85) among men ≥60 years (T3 vs T1/T2; adjusted for height, heart rate, CVD risk factors). No association was found in females. A stronger predictive ability was observed in younger males, with AIx values above the reference limit (HR 3.15 (95% CI 1.73–5.74), multivariable-adjusted). Finally, an increased AIx was also associated with almost 2-fold higher prevalence of CVD in males <60 years (Prevalence ratio 1.81 (95% CI 1.33–2.45) for T3 vs T1/T2; or 2.01 (95% CI 1.40–2.86) for AIx values above reference in a fully adjusted model), but not in older males or women.

Conclusion: Within the present analysis, AIx demonstrated a strong predictive value for prevalent CVD and worse survival in younger males, thereby underlying its clinical usefulness in this particular population.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
25 - Supplement 1
Pages
S3 - S3
Publication Date
2020/02/15
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.191224.003How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Natalie Arnold
AU  - Tommaso Gori
AU  - Anika Gündling
AU  - Andreas Schulz
AU  - Jürgen H. Prochaska
AU  - Marina Panova-Noeva
AU  - Irene M. Schmidtmann
AU  - Norbert Pfeiffer
AU  - Manfred Beutel
AU  - Karl J. Lackner
AU  - Thomas Münzel
AU  - Philipp S Wild
PY  - 2020
DA  - 2020/02/15
TI  - 1.4 Prognostic Relevance of Augmentation Index in Prevalent Cardiovascular Disease and Total Mortality: Data From the General Population
JO  - Artery Research
SP  - S3
EP  - S3
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.003
DO  - 10.2991/artres.k.191224.003
ID  - Arnold2020
ER  -