2.5 Differential Association of Central and Peripheral Arterial Compliance with Resting and Recruitable Endothelial Function in Healthy Human Subjects

DOI

10.2991/artres.k.191224.010How to use a DOI?

Abstract

Background: Regional arterial compliance in peripheral arteries is known to be associated with ‘recruitable’ endothelial function probably mediated by an increase in smooth muscle tone [1]. However, the association between regional arterial stiffness and ‘resting’ endothelial function has not been evaluated.

Methods: Low Flow Mediated Constriction (LFMC) and Flow Mediated Dilation (FMD) were measured to evaluate ‘resting’ and ‘recruitable’ endothelial function as change in diameter of the brachial artery (ΔD) during and after 5 minutes of suprasystolic occlusion of the forearm in comparison to baseline artery diameter using B-mode ultrasound (M7, MindRay) in 27 healthy subjects (Age 50.8 ± 9.6 years). Central and peripheral regional arterial stiffness was assessed using applanation tonometry (SphygmocorÒ) to calculate carotid-femoral(cf) and carotid-radial(cr) Pulse Wave Velocity (PWV) respectively.

Results: FMD showed a significant negative correlation with crPWV (r = −0.39, p = 0.04) (Figure 1) while LFMC did not correlate with peripheral arterial stiffness. A significant negative correlation was observed between LFMC and cfPWV (r = −0.53, p = 0.006) (Figure 2) but not between FMD and cfPWV.

Figure 1

Correlation between recruitable endothelial function assessed by flow mediated dilation and peripheral arterial stiffness assessed by carotid-radial Pulse Wave Velocity.

Figure 2

Correlation between resting endothelial function assessed by low flow mediated constriction and central arterial stiffness assessed by carotid-femoral Pulse Wave Velocity.

Conclusion: Impaired NO bioavailability has been identified as the key mechanism associated with reduced FMD and may result in increased smooth muscle tone thereby contributing to a functional decrease in peripheral arterial compliance. The results of the current study suggest that withdrawal of resting vasodilatory influence of NO may not be a major factor involved in LFMC. The exact mechanisms associating resting endothelial function with structural arterial stiffness in the central vessels needs to be further investigated.

Copyright

© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Smriti Badhwar
AU  - Dinu Chandran
AU  - Ashok Jaryal
AU  - Rajiv Narang
AU  - Chetan Patel
AU  - Kishore Kumar Deepak
PY  - 2020
DA  - 2020/02/15
TI  - 2.5 Differential Association of Central and Peripheral Arterial Compliance with Resting and Recruitable Endothelial Function in Healthy Human Subjects
JO  - Artery Research
SP  - S13
EP  - S14
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.010
DO  - 10.2991/artres.k.191224.010
ID  - Badhwar2020
ER  -