5.5 MEASUREMENT OF ARTERIAL STIFFNESS BY ULTRAFAST ECHO: COMPARISON WITH ECHOTRACKING IN NORMOTENSIVE SUBJECTS AND HYPERTENSIVE PATIENTS

Louise Marais*; Mathieu Pernot; Hakim Khettab; Mickael Tanter; Emmanuel Messas; Mustapha Zidi; Stéphane Laurent; Pierre Boutouyrie

doi:10.1016/j.artres.2015.10.030

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Volume 12, Issue C, December 2015, Pages 46 - 46

5.5 MEASUREMENT OF ARTERIAL STIFFNESS BY ULTRAFAST ECHO: COMPARISON WITH ECHOTRACKING IN NORMOTENSIVE SUBJECTS AND HYPERTENSIVE PATIENTS

Authors

Louise Marais*¹^{, 2}, Mathieu Pernot³, Hakim Khettab¹, Mickael Tanter³, Emmanuel Messas¹^{, 4}, Mustapha Zidi², Stéphane Laurent¹^{, 4}, Pierre Boutouyrie¹^{, 4}

¹PARCC Inserm U970, Georges Pompidou European Hospital, Paris, France

²Bioengineering Tissues and Neuroplasticity, EA 7377, Paris Est Créteil University, Créteil, France

³Institut Langevin, ESPCI-ParisTech, CNRS UMR 7587, Inserm U979, Paris, France

⁴Paris Descartes University, Paris, France

Available Online 23 November 2015.

DOI: 10.1016/j.artres.2015.10.030 How to use a DOI?
Abstract: Because measurement of arterial stiffness is highly dependent on blood pressure (BP), methods independent of BP are required. Ultrafast echography (UFE, Supersonic Imagine, Aix en Provence, France) makes use of very fast sampling rate (up to 10 kHz), so transient events such as pressure wave arrival can be tracked. This method has never been tested against classical echotracking (Artlab, Esaote, Maastricht, NL) and carotid-femoral pulse wave velocity (cf-PWV, Sphygmocor, AtCor, Sydney, Australia).

We included 56 subjects, 27 normotensives (NT) and 29 essential hypertensives (HT), matched for age and sex. We optimized UFE algorithms for pressure wave detection and tracking, for both foot of the wave (FW) and dicrotic notch (DN) PWV.

Feasibility appears good (FW: 78%, DN: 96%). The relations of arterial stiffness with age and blood pressure were stronger for echotracking and cf-PWV than for UFE. DN wave fronts appeared better associated with cf-PWV (r = 0.32, p < 0.001) and carotid PWV (r = 0.47, p < 0.001). FW was not associated with cf-PWV nor with carotid PWV. The residuals between DN and carotid PWV were not associated with BP or age. Similar associations between DN and cf-PWV/carotid PWV were found in NT and HT.

Conclusion: After optimizing algorithms for wave front identification and tracking, UFE appears as a promising technique for assessing arterial stiffness. DN showed the best associations with echotracking, whereas FW did not provide meaningful data. As previously shown by Hermeling et al (J Hypertens 2008 and 2009), FW is not appropriate for local stiffness measurement likely because of very early wave reflections.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 12 - C
Pages: 46 - 46
Publication Date: 2015/11/23
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2015.10.030 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Louise Marais*
AU  - Mathieu Pernot
AU  - Hakim Khettab
AU  - Mickael Tanter
AU  - Emmanuel Messas
AU  - Mustapha Zidi
AU  - Stéphane Laurent
AU  - Pierre Boutouyrie
PY  - 2015
DA  - 2015/11/23
TI  - 5.5 MEASUREMENT OF ARTERIAL STIFFNESS BY ULTRAFAST ECHO: COMPARISON WITH ECHOTRACKING IN NORMOTENSIVE SUBJECTS AND HYPERTENSIVE PATIENTS
JO  - Artery Research
SP  - 46
EP  - 46
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.030
DO  - 10.1016/j.artres.2015.10.030
ID  - Marais*2015
ER  -

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