3.1 PREDIABETES IS ASSOCIATED WITH IMPAIRED RETINAL VASODILATION: THE MAASTRICHT STUDY

DOI

10.1016/j.artres.2015.10.014How to use a DOI?

Abstract

Aim: Type 2 diabetes (DM2) causes microvascular dysfunction (MVD). In addition, MVD can contribute to insulin resistance, predisposing to DM2. This hypothesis predicts that MVD should be present in impaired glucose metabolism (IGM; prediabetes). However, population-based studies of MVD and glucose metabolism are not available. We investigated this using the retinal arteriolar dilator response to flicker light.

Methods: In a population-based study (n = 2205), we determined retinal %-dilation (Dynamic Vessel Analyzer; Imedos, Germany) and glucose metabolism status (OGTT; classified as normal (NGM), IGM or DM2). Differences were compared with multivariable regression adjusted for age, sex, BMI, smoking, systolic-BP, lipid profile, retinopathy, (micro)albuminuria, the use of lipid-modifying and/or blood-pressure-lowering medication and prior cardiovascular disease.

Results: 1263 individuals had NGM (42% men, aged 58 ± 8 years (mean ± SD)), 336 IGM (61% men, aged 61 ± 7 years) and 606 (due to oversampling) DM2 (69% men, aged 63 ± 8 years). Arteriolar %-dilation was median 3.51, IQR 1.47 to 5.95, range −5.69 to +19.71. %-dilation (mean ± SD) was 4.42 ± 3.45 in NGM, 3.77 ± 3.06 in IGM, and 3.26 ± 3.27 in DM2. Adjusted analyses showed decreased %-dilation in IGM (β = −0.461, p = 0.03) and DM2 (β = 0.559, p = 0.01) vs NGM.

Conclusion: IGM and DM2 are associated with reduced flicker-light-induced retinal arteriolar dilation, independently of major cardiovascular risk factors. These findings support the concept that MVD precedes and thus may contribute to DM2.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Ben Sörensen*
AU  - Boy Houben
AU  - Tos Berendschot
AU  - Jan Schouten
AU  - Bram Kroon
AU  - Carla van der Kallen
AU  - Ronald Henry
AU  - Annemarie Koster
AU  - Pieter Dagnelie
AU  - Nicolaas Schaper
AU  - Miranda Schram
AU  - Coen Stehouwer
PY  - 2015
DA  - 2015/11/23
TI  - 3.1 PREDIABETES IS ASSOCIATED WITH IMPAIRED RETINAL VASODILATION: THE MAASTRICHT STUDY
JO  - Artery Research
SP  - 42
EP  - 42
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.014
DO  - 10.1016/j.artres.2015.10.014
ID  - Sörensen*2015
ER  -