Artery Research

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Volume 12, Issue C, December 2015, Pages 44 - 44

4.3 THE EFFECT OF GLYCAEMIC STATE TRANSITION ON ACCELERATED AORTIC STIFFENING: A LONGITUDINAL STUDY IN THE WHITEHALL II COHORT

Authors
Nanna B. Johansen*1, 2, Martin Shipley3, Daniel R. Witte2, 4, Adam G. Tabak3, 5, Eric J. Brunner3
1Clinical Epidemiology, Steno Diabetes Center A/S, Gentofte, Denmark
2Danish Diabetes Academy, Odense, Denmark
3UCL Research Department of Epidemiology and Public Health, London, UK
4Department of Public Health, University of Aarhus, Aarhus, Denmark
5Semmelweis University Faculty of Medicine, 1st Department of Medicine, Budapest, Hungary
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.022How to use a DOI?
Abstract

In 4,759 participants from the Whitehall II study, we examined the impact of glycaemic history on aortic stiffening. Assessment of aortic stiffness by carotid-femoral pulse wave velocity (PWV) was performed twice with a 4 year interval (2007–2009 and 2012–2013). At the first aortic stiffness assessment and 5 years earlier (2002–2004 and 2007–2009 respectively), participants were categorised into 3 groups based on measurements of fasting plasma glucose (FPG), 2-hour plasma glucose (2hPG), and HbA1c: normoglycaemia, dysglycaemia and type 2 diabetes. The impact of 5-year glycaemic state transition on PWV and PWV changes was analysed by mixed effect models adjusting for relevant confounders. In participants who had normoglycaemia on FPG, 2hPG and HbA1c on both examinations, PWV was 8.3 m/s at baseline and increased by 0.4 m/s during 4 years. Those who progressed to dysglycaemia had a 0.3 m/s (95% CI: 0.1;0.5) steeper increase in PWV compared with stable normoglycaemia, whereas those who progressed to diabetes did not have a statistical significantly steeper increase in PWV (0.1 m/s (95% CI: −0.4; 0.6)). Participants with diabetes at both examinations had a markedly larger increase in PWV of 0.6 m/s (95% CI: 0.3;0.9) compared to participants with stable normoglycaemia. For other glycaemic state combinations there was a tendency towards a steeper increase in PWV compared with stable normoglycaemia, however not statistically significant. These results indicate that people with diabetes or deteriorating dysglycaemia, experience accelerated aortic stiffening; suggesting that prevention of dysglycaemic progression and diabetes may have a beneficial effect on the progression of aortic stiffness.

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Journal
Artery Research
Volume-Issue
12 - C
Pages
44 - 44
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.022How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Nanna B. Johansen*
AU  - Martin Shipley
AU  - Daniel R. Witte
AU  - Adam G. Tabak
AU  - Eric J. Brunner
PY  - 2015
DA  - 2015/11/23
TI  - 4.3 THE EFFECT OF GLYCAEMIC STATE TRANSITION ON ACCELERATED AORTIC STIFFENING: A LONGITUDINAL STUDY IN THE WHITEHALL II COHORT
JO  - Artery Research
SP  - 44
EP  - 44
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.022
DO  - 10.1016/j.artres.2015.10.022
ID  - Johansen*2015
ER  -