1.4 CHILDHOOD DETERMINANTS OF EARLY ADULT ARTERIAL STIFFNESS IN DIFFERENT ETHNIC GROUPS

K.J. Cruickshank; L. Faconti*; M.J. Silva; O.R. Molaodi; Z.E. Enayat; A. Cassidy; A. Karamanos; U.M. Read; P. Dall; B. Stansfield; S. Harding

doi:10.1016/j.artres.2015.10.005

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Volume 12, Issue C, December 2015, Pages 40 - 40

1.4 CHILDHOOD DETERMINANTS OF EARLY ADULT ARTERIAL STIFFNESS IN DIFFERENT ETHNIC GROUPS

Authors

K.J. Cruickshank¹, L. Faconti*¹, M.J. Silva¹, O.R. Molaodi², Z.E. Enayat¹, A. Cassidy², A. Karamanos¹, U.M. Read¹, P. Dall², B. Stansfield², S. Harding¹

¹Cardiovascular Medicine & Social Epidemiology Group, Division of Diabetes & Nutritional Sciences, Kings College London, London, UK

²Social and Public Health Sciences Unit, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK

Available Online 23 November 2015.

DOI: 10.1016/j.artres.2015.10.005 How to use a DOI?
Abstract: Childhood determinants of aortic pulse wave velocity [PWV] are poorly understood. We tested how factors measured twice previously in childhood in the MRC ‘DASH’ study, particularly body mass (BMI) components and BP, affected PWV in young adults.

Methods: Of 6643 London children, aged 11–13 y, from 51 schools in samples of about 1000 in 6 ethnic groups, with markedly different adult cardiovascular risk, 4785 (72%), were seen again at 14–16 y. In 2013, 666 (97% of invited) took part in a young-adult pilot (21–23 y) follow-up. With psychosocial, anthropometric and BP measures, PWV was recorded via an upper arm cuff on the calibrated Arteriograph device. In a subsample (n = 334) PA was measured over 5 days via the ActivPal.

Results: Unadjusted PWVs in Black Caribbean and White UK young men were similar (mean+SD 7.9 + 0.3 vs 7.6 + 0.4 m/sec) and lower in other groups at similar systolic (s)BPs (120 mmHg) and BMIs (24.6 kg/m²). In fully adjusted regression models, independent of BP effects, while Black Caribbean (higher BMIs and waists), Black African and Indian young women had lower PWV (by 0.5–0.8, 95%CI 0.1–1.1 m/sec) than White UK women (6.9 + 0.2 m/sec), values were still increased by age, BP, powerful impacts from waist/height and time spent sedentary but a reducing impact of time walking >100steps/min (both p < 0.01), with a racism effect (+0.4 m/sec) in women. Childhood effects of waist/hip were also detectable.

Conclusion: Even by young adulthood, increased waist/height ratios, lower physical activity, BP and psychosocial variables (eg: perceived racism) are independent determinants of arterial stiffness, likely to increase with age.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 12 - C
Pages: 40 - 40
Publication Date: 2015/11/23
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2015.10.005 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - K.J. Cruickshank
AU  - L. Faconti*
AU  - M.J. Silva
AU  - O.R. Molaodi
AU  - Z.E. Enayat
AU  - A. Cassidy
AU  - A. Karamanos
AU  - U.M. Read
AU  - P. Dall
AU  - B. Stansfield
AU  - S. Harding
PY  - 2015
DA  - 2015/11/23
TI  - 1.4 CHILDHOOD DETERMINANTS OF EARLY ADULT ARTERIAL STIFFNESS IN DIFFERENT ETHNIC GROUPS
JO  - Artery Research
SP  - 40
EP  - 40
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.005
DO  - 10.1016/j.artres.2015.10.005
ID  - Cruickshank2015
ER  -

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