1.5 RELATION OF ARTERIAL STIFFNESS WITH LEFT VENTRICULAR DIASTOLIC FUNCTION IN GENERAL POPULATION

Wiktoria Wojciechowska*; Katarzyna Stolarz-Skrzypek; Agnieszka Olszanecka; Lukasz Klima; Jerzy Gasowski; Tomasz Grodzicki; Kalina Kawecka-Jaszcz; Danuta Czarnecka

doi:10.1016/j.artres.2015.10.006

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Volume 12, Issue C, December 2015, Pages 40 - 40

1.5 RELATION OF ARTERIAL STIFFNESS WITH LEFT VENTRICULAR DIASTOLIC FUNCTION IN GENERAL POPULATION

Authors

Wiktoria Wojciechowska*¹, Katarzyna Stolarz-Skrzypek¹, Agnieszka Olszanecka¹, Lukasz Klima¹, Jerzy Gasowski², Tomasz Grodzicki², Kalina Kawecka-Jaszcz¹, Danuta Czarnecka¹

¹I Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University, Medical College, Krakow, Poland

²Department of Internal Medicine and Gerontology, Jagiellonian University, Medical College, Krakow, Poland

Available Online 23 November 2015.

DOI: 10.1016/j.artres.2015.10.006 How to use a DOI?
Abstract: Left ventricular diastolic function declines with aging and hypertension. It is well known that elevated blood pressure results in increased arterial stiffness. The study aims to determine the relationship between arterial stiffness and left ventricular diastolic function in general population.

Methods: We recruited 303 (mean age, 46.9 years; 167 women, 155 normotensives) members of randomly recruited families. Normotension and hypertension were diagnosed based on both office and ambulatory blood pressure measurements, or history of antihypertensive treatment. Pulse wave velocity (PWV), peripheral and central pulse pressure (pPP; cPP) were evaluated by means of pulse wave analysis. Left ventricle (LV) diastolic function was determined by measuring transmitral (early (E) and late (A) diastolic peak velocities and E/A ratio) and pulmonary (peak systolic (S) and diastolic (D) velocity and S/D ratio) flow velocities and diastolic velocities of septal and lateral mitral annulus (E′ wave and E/E′ ratio) obtained in tissue doppler. Additionaly we measured left atrium diameter (LAd).

Results: After adjusting for relatedness, pPP, cPP and PWV were negatively associated with E/A, and positively with E/E′ and S/D (P < 0.001). In multivariate analysis the most closely related parameters were: cPP with E/E′(β = 0.04, P = 0.001), cPP with S/D (β = −0.004, P = 0.011), and pPP with E/E′ (β = −0.03, P = 0.003). Additionally pPP was associated with LAd (β = 0.058, P = 0.011). In hypertensives pPP and cPP related both to E/E′ and S/D (p < 0.01).

Conclusions: Our study suggested that increased arterial stiffness as estimated by pulse pressure measurement might be considered as a determinant of left ventricular diastolic dysfunction.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 12 - C
Pages: 40 - 40
Publication Date: 2015/11/23
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2015.10.006 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Wiktoria Wojciechowska*
AU  - Katarzyna Stolarz-Skrzypek
AU  - Agnieszka Olszanecka
AU  - Lukasz Klima
AU  - Jerzy Gasowski
AU  - Tomasz Grodzicki
AU  - Kalina Kawecka-Jaszcz
AU  - Danuta Czarnecka
PY  - 2015
DA  - 2015/11/23
TI  - 1.5 RELATION OF ARTERIAL STIFFNESS WITH LEFT VENTRICULAR DIASTOLIC FUNCTION IN GENERAL POPULATION
JO  - Artery Research
SP  - 40
EP  - 40
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.006
DO  - 10.1016/j.artres.2015.10.006
ID  - Wojciechowska*2015
ER  -

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