P8.7 VASCULAR ENDOTHELIAL SENESCENCE AND METABOLIC SYNDROME

DOI

10.1016/j.artres.2015.10.329How to use a DOI?

Abstract

Objectives: Vascular aging and metabolic syndrome (MS) are both independent predictors of cardiovascular events. We examined whether MS accelerates the progression of vascular aging.

Methods: 142 subjects (mean age 51.9±10.8 years, 94 men) with no established cardiovascular disease were investigated in 2 examinations over a 2-year period (mean follow-up visit 1.84 years). MS was defined by the ATP III criteria. Subjects had at the beginning and end of the study determinations of carotid-femoral pulse wave velocity (PWV), aortic augmentation index corrected for heart rate (AIx75), brachial flow-mediated dilatation (FMD) and carotid intima-media thickness (cIMT). Based on these measurements the annual absolute changes were calculated.

Results: At baseline patients with MS compared with patients without MSs had lower values of FMD (6.0% vs. 7.0%, P=0.025), but there were no statistically significant differences for PWV (7.04m/s vs. 7.26m/s, P=0.242), AIx@75 (19.9% vs. 20.3%, P=0.846) and cIMT (0.68mm vs. 0.68mm, P=0.957). For the overall population, there were no statistically significant differences in the annual absolute changes of PWV, FMD, AIx75 and cIMT. However, when a subgroup of patients <60 years with more rapid progression of endothelial aging was investigated, MS was associated with almost 7 times higher annual change of FMD [−0.89% (95% CI:−1.50 to −0.28) in patients with MS vs. −0.13% (95% CI:−0.36 to 0.10) in patients without MS, P=0.032]. This difference was not evident in the other vascular biomarkers.

Conclusions: Presence of MS is associated with endothelial dysfunction as well as accelerated progression of endothelial dysfunction, especially in the younger subjects.

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TY  - JOUR
AU  - Dimitrios Terentes-Printzios*
AU  - Charalambos Vachopoulos
AU  - Nikolaos Ioakeimidis
AU  - Athanasios Aggelis
AU  - Panagiotis Xaplanteris
AU  - Panagiota Pietri
AU  - Dimitrios Tousoulis
PY  - 2015
DA  - 2015/11/23
TI  - P8.7 VASCULAR ENDOTHELIAL SENESCENCE AND METABOLIC SYNDROME
JO  - Artery Research
SP  - 35
EP  - 36
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.329
DO  - 10.1016/j.artres.2015.10.329
ID  - Terentes-Printzios*2015
ER  -