1.2 AGE-DEPENDENT ASSOCIATION OF 24-HOUR PERIPHERAL AND CENTRAL PULSE PRESSURES WITH STROKE VOLUME

Giacomo Pucci*; Francesca Battista; Fabio Anastasio; Mariano Edoardo Crapa; Leandro Sanesi; Giuseppe Schillaci

doi:10.1016/j.artres.2015.10.003

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Volume 12, Issue C, December 2015, Pages 39 - 39

1.2 AGE-DEPENDENT ASSOCIATION OF 24-HOUR PERIPHERAL AND CENTRAL PULSE PRESSURES WITH STROKE VOLUME

Authors

Giacomo Pucci*¹^{, 2}, Francesca Battista¹^{, 2}, Fabio Anastasio¹^{, 2}, Mariano Edoardo Crapa¹^{, 2}, Leandro Sanesi¹^{, 2}, Giuseppe Schillaci¹^{, 2}

¹Unit of Internal Medicine, Terni University Hospital, Terni, Italy

²Department of Medicine, University of Perugia, Perugia, Italy

Available Online 23 November 2015.

DOI: 10.1016/j.artres.2015.10.003 How to use a DOI?
Abstract: Objective: Pulse pressure (PP) is a complex physiologic trait affected by many variables, including LV contractility (reflected by stroke volume), arterial stiffness, and central-to-brachial amplification.The impact of age on the relationship between stroke volume and central or brachial PP has not been investigated.

Methods: 3765 untreated hypertensive adults (men 56%, age 50 ± 12 years) underwent 24-hour ambulatory BP monitoring (SpaceLabs) and M-mode echocardiography. In a subset of 982 subjects in whom central PP was measured by applying a transfer function to radial pulse wave (SphygmoCor), we also estimated central office (or 24 h) PP by regression equations based on office (or 24 h) PP and MAP, heart rate, age, height and sex (R2 = 0.92 between estimated and measured central PP).The same equations were then applied to the original population to obtain estimated central PP.

Results: Stroke volume had a significant direct association with both brachial and central 24 h PP up to the age of 39 years. The above relationship weakened with age and became mostly non-significant after the age of 40 (all r < 0.10). Similar, although weaker, trends were observed for office PP (both brachial and central).

Conclusions: 24-h PP has a strong direct association with LV stroke volume in the young only, and might more exclusively depend on arterial stiffness later in life. Since the above relationship was also observed with estimated central PP, it may not depend on PP amplification. The “young” and “old” pathophysiological patterns of PP may help to explain the increasingly adverse prognostic value of PP observed with advancing age.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 12 - C
Pages: 39 - 39
Publication Date: 2015/11/23
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2015.10.003 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Giacomo Pucci*
AU  - Francesca Battista
AU  - Fabio Anastasio
AU  - Mariano Edoardo Crapa
AU  - Leandro Sanesi
AU  - Giuseppe Schillaci
PY  - 2015
DA  - 2015/11/23
TI  - 1.2 AGE-DEPENDENT ASSOCIATION OF 24-HOUR PERIPHERAL AND CENTRAL PULSE PRESSURES WITH STROKE VOLUME
JO  - Artery Research
SP  - 39
EP  - 39
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.003
DO  - 10.1016/j.artres.2015.10.003
ID  - Pucci*2015
ER  -

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