1.1 DIASTOLIC LEFT VENTRICULAR FUNCTION IN RELATION TO CIRCULATING METABOLIC BIOMARKERS IN A GENERAL POPULATION

Zhen Yu Zhang*; Vannina Marrachelli; Lutgarde Thijs; Wen Yi Yang; Fang Fei Wei; Daniel Monleon; Lotte Jacobs; Tim Nawrot; Peter Verhamme; Jens-Uwe Voigt; Tatiana Kuznetsova; Josep Redón; Jan Staessen

doi:10.1016/j.artres.2015.10.002

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Volume 12, Issue C, December 2015, Pages 39 - 39

1.1 DIASTOLIC LEFT VENTRICULAR FUNCTION IN RELATION TO CIRCULATING METABOLIC BIOMARKERS IN A GENERAL POPULATION

Authors

Zhen Yu Zhang*¹, Vannina Marrachelli², Lutgarde Thijs¹, Wen Yi Yang¹, Fang Fei Wei¹, Daniel Monleon², Lotte Jacobs¹, Tim Nawrot³^{, 4}, Peter Verhamme⁵, Jens-Uwe Voigt⁶, Tatiana Kuznetsova¹, Josep Redón²^{, 7}, Jan Staessen¹^{, 8}

¹Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven, Leuven, Belgium

²Metabolomic and Molecular Image Laboratory, Fundación Investigatión Clínico de Valencia, Valencia, Spain

³Centre for Environmental Sciences, University of Hasselt, Diepenbeek, Belgium

⁴Research Unit Environment and Health, KU Leuven Department of Public Health and Primary Care, University of Leuven, Leuven, Belgium

⁵Centre for Molecular and Vascular Biology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium

⁶Research Unit Cardiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, leuven, Belgium

⁷Hypertension Unit, Division of Internal Medicine, Hospital Clinico, University of Valencia, Valencia, Spain

⁸R & D Group VitaK, Maastricht University, Maastricht, The Netherlands

Available Online 23 November 2015.

DOI: 10.1016/j.artres.2015.10.002 How to use a DOI?
Abstract: Background: The metabolic signature associated with subclinical diastolic left ventricular (LV) dysfunction in the general population is unknown.

Objectives: This population study aimed at identifying a specific profile of circulating me-tabolites associated with asymptomatic diastolic LV dysfunction.

Methods: In 711 randomly recruited Flemish (50.8% women; mean age, 50.8 years), we assessed echocardiographic indexes of diastolic LV function in relation to 44 circulating metabolites determined by nuclear magnetic resonance spectroscopy. Statistical methods included multivariable-adjusted regression analyses and partial least square discriminant analysis (PLS DA).

Results: In multivariable analyses with Bonferroni correction, a′ was inversely and e′/a′ was positively correlated (p ≤ 0.048) with circulating tyrosine, HDL apolipoproteins, glucose + glutamine, and an unidentified molecule, while a′ was also inversely associated with glucose + 2 aminobutyrate and glucose + 2 phosphoglycerate (p ≤ 0.031). PLS-DA identified three latent factors accounting for 54.4% of the variance. The metabolites associated with better diastolic LV function included, amongst others, glucose + glutamine (variable importance in projection score, 1.201), glucose + 2 aminobutyrate (1.185), and glucose + 2 phosphoglycerate (1.172). The three latent factors, compared with N-terminal prohormone brain natriuretic peptide, increased (p < 0.0001) the area under the curve from 0.64 to 0.73.

Conclusions: In the general population, diastolic LV function is associated with a profile of circulating metabolites indicative of energy substrate utilization and protection against oxidative stress. These metabolic markers might lead to the discovery of new targets for prevention and treatment of diastolic LV dysfunction at a subclinical and still reversible stage.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 12 - C
Pages: 39 - 39
Publication Date: 2015/11/23
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2015.10.002 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Zhen Yu Zhang*
AU  - Vannina Marrachelli
AU  - Lutgarde Thijs
AU  - Wen Yi Yang
AU  - Fang Fei Wei
AU  - Daniel Monleon
AU  - Lotte Jacobs
AU  - Tim Nawrot
AU  - Peter Verhamme
AU  - Jens-Uwe Voigt
AU  - Tatiana Kuznetsova
AU  - Josep Redón
AU  - Jan Staessen
PY  - 2015
DA  - 2015/11/23
TI  - 1.1 DIASTOLIC LEFT VENTRICULAR FUNCTION IN RELATION TO CIRCULATING METABOLIC BIOMARKERS IN A GENERAL POPULATION
JO  - Artery Research
SP  - 39
EP  - 39
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.002
DO  - 10.1016/j.artres.2015.10.002
ID  - Zhang*2015
ER  -

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