P7.7 TESTOSTERONE LEVELS IN HYPERTENSIVE PATIENTS WITH VASCULAR ORGAN DAMAGE

DOI

10.1016/j.artres.2015.10.310How to use a DOI?

Abstract

Purpose: Testosterone levels are decreased in hypertensive patients compared to normotensive subjects with similar age. Measurements of carotid IMT or aortic stiffness are reasonable for detecting vascular organ damage (OD) in patients with arterial hypertension. We investigated whether low testosterone concentration is associated with vascular OD in hypertensive patients.

Methods: 178 consecutive asymptomatic hypertensive males (40–60 y/o) were evaluated using exercise treadmill test and stress echocardiography. Men with positive one or both of the two tests were referred for coronary angiography in order to document coronary artery disease (CAD). All patients underwent carotid-femoral pulse wave velocity (PWV) and carotid IMT evaluation. Vascular OD was detected when IMT>0.9 mm (or plaque) and/or PWV>10 m/s. Total testosterone (TT) levels were measured in all participants. Testosterone deficiency (TD) was defined when TT levels were below 3.4 ng/ml.

Results: Coronary angiography revealed significant stenosis in 31 (17%) patients. The prevalence of Grade II/III hypertension was not different between CAD patients and subjects without CAD. Subjects without CAD were further divided according to presence/absence of vascular OD. Patients with vascular OD had lower TT level (p<0.001) and a greater prevalence of TD (p<0.01) compared to hypertensive subjects without OD after adjustment for age and blood pressure. Interestingly, CAD patients and non CAD subjects with vascular OD had comparable TT concentration and prevalence of TD.

Conclusion: TT concentration is decreased in hypertensive patients with vascular OD compared to subjects without OD. These findings underscore the predictive value of TD in hypertensive males with OD.

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TY  - JOUR
AU  - Dimitrios Terentes-Printzios*
AU  - Charalambos Vlachopoulos
AU  - Nikolaos Ioakeimidis
AU  - Athanassios Angelis
AU  - Panagiota Pietri
AU  - Mahmoud Abdelrasoul
AU  - Christos Georgakopoulos
AU  - Dimitris Tousoulis
PY  - 2015
DA  - 2015/11/23
TI  - P7.7 TESTOSTERONE LEVELS IN HYPERTENSIVE PATIENTS WITH VASCULAR ORGAN DAMAGE
JO  - Artery Research
SP  - 31
EP  - 31
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.310
DO  - 10.1016/j.artres.2015.10.310
ID  - Terentes-Printzios*2015
ER  -