Artery Research

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Volume 12, Issue C, December 2015, Pages 34 - 34

P8.1 CENTRAL HEMODYNAMICS IN SYSTEMIC SCLEROSIS: A CASE-CONTROL STUDY

Authors
Francesca Battista*1, 2, Giacomo Pucci1, 2, Elena Bartoloni Bocci1, 3, Francesca Cannarile1, 3, Alessia Alunno1, 3, Fabio Anastasio1, 2, Roberto Gerli1, 3, Giuseppe Schillaci1, 2
1Department of Medicine University of Perugia, Perugia, Italy
2Unit of Internal Medicine Terni University Hospital, Terni, Italy
3Unit of Rheumatology Perugia University Hospital, Perugia, Italy
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.324How to use a DOI?
Abstract

Background: Although a few studies have suggested an alteration in aortic stiffness in patients with systemic sclerosis (SS), a disease characterized by immunological and microvascular changes and by tissue fibrosis, the functional properties of the large arteries have been understudied in SS.

Methods: 34 women with SS [age 60±14 years, BP 123/70±17/10 mmHg] and 34 healthy age- and BP-matched women underwent determination of carotid-femoral pulse wave velocity (PWV, a direct measure of aortic stiffness) and aortic augmentation (SphygmoCor, AtCor). All participants also underwent determination of carotid-radial PWV, as a measure of stiffness of upper-limb arteries. We excluded participants with overt cardiovascular disease and concomitant important disease.

Results: Age and brachial BP were nearly identical in the 2 groups. Patients and controls did not differ by carotid-femoral PWV (9.2±3 vs 9.1±2 m/s, p=0.91) or carotid-radial PWV. Aortic augmentation, was higher in women with SS; unadjusted: 16.1±8 vs 11.5±7, p=0.014; adjusted for pulse pressure and heart rate (AIx@75): 30.9±16 vs 22.2±12, p=0.012). SS independently predicted AIx@75 in a multivariate analysis. Among patients with SS, age, brachial mean BP and serum C-reactive protein all predicted carotid-femoral PWV. Age and mean BP were the only predictors of AIx@75. Organ damage scores had no significat correlation with central hemodynamics parameters.

Conclusions: SS is associated with an increase in aortic augmentation (as a measure of the contribution of reflected wave to central waveform), but not in aortic or upper-limb arterial stiffness. Microvascular involvement might occur earlier than stiffening of the large arteries in SS.

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Journal
Artery Research
Volume-Issue
12 - C
Pages
34 - 34
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.324How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Francesca Battista*
AU  - Giacomo Pucci
AU  - Elena Bartoloni Bocci
AU  - Francesca Cannarile
AU  - Alessia Alunno
AU  - Fabio Anastasio
AU  - Roberto Gerli
AU  - Giuseppe Schillaci
PY  - 2015
DA  - 2015/11/23
TI  - P8.1 CENTRAL HEMODYNAMICS IN SYSTEMIC SCLEROSIS: A CASE-CONTROL STUDY
JO  - Artery Research
SP  - 34
EP  - 34
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.324
DO  - 10.1016/j.artres.2015.10.324
ID  - Battista*2015
ER  -