P6.19 GENDER DIFFERENCES OF ARTERIAL STIFFNESS AND CENTRAL BLOOD PRESSURE IN PATIENTS WITH ARTERIAL HYPERTENSION AND THE INFLUENCE OF MENOPAUSE

Valéria Costa-Hong; Henrique Muela; Allan Sales; Luiz Bortolotto*

doi:10.1016/j.artres.2015.10.303

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Volume 12, Issue C, December 2015, Pages 29 - 29

P6.19 GENDER DIFFERENCES OF ARTERIAL STIFFNESS AND CENTRAL BLOOD PRESSURE IN PATIENTS WITH ARTERIAL HYPERTENSION AND THE INFLUENCE OF MENOPAUSE

Authors

Valéria Costa-Hong¹, Henrique Muela¹, Allan Sales², Luiz Bortolotto*¹

¹Heart Institute (Incor), University of São Paulo Medical School, Hypertension Unit, São Paulo, São Paulo, Brazil

²Heart Institute (Incor), University of São Paulo Medical School, Cardiovascular Rehabilitation and Exercise Physiology Unit, São Paulo, São Paulo, Brazil

Available Online 23 November 2015.

DOI: 10.1016/j.artres.2015.10.303 How to use a DOI?
Abstract: Introduction: In general population women seems to have greater arterial stiffness and central blood pressure(BP), measured by augmentation index (AIx), than men, but in hypertension this condition is poorly studied.

Objectives: To evaluate differences of central BP and arterial stiffness between men and women with arterial hypertension and the influence of postmenopausal status.

Methods: We studied 128 subjects with stage 1–3 arterial hypertension, mean age 51.1±11 years, 48% males, BP = 141±24/87±13 mmHg, hypertension duration 10.1±8 years. Noninvasive central aortic BP and wave form characteristics (Alx and AIx corrected by heart rate of 75 bpm – Alx75) were synthesized from radial arterial pressure waves (applanation tonometry) by SphygmoCor^®. Brachial BP was obtained by an automatic device(OMRON^®).

Results: Brachial systolic BP was higher (145±26 vs. 136±20 mmHg, p=0.04) and, weight (76.2±14 vs. 86.4±13.2, p<0.01) and height (1.59±0.06 vs. 1.72±0.08, p<0.01) were lower in females than in males. Central systolic BP (137±30 vs 125±23 mmHg, p<0.01), Alx(32.7±9.8 vs 19.5±11.7, p<0.01), Alx75(29.6±6.9 vs 18.0±9.3, p<0.01) were higher in females, even after adjustments for weight, height and systolic BP. Postmenopausal status was present in 70% of females and mean age of menopause beginning was 47.8 years. Women at postmenopausal status older than 48 years showed worse Alx(35.3 ± 9.4) than younger women(26.8 ± 8.9) and also than men(23.2 ± 12.4) at same age(p<0.05).

Conclusions: Hypertensive females have higher brachial and central systolic BP than hypertensive males. Arterial stiffness is higher in hypertensive females than in men, at all ages, and in postmenopausal status is worse than in fertile period.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 12 - C
Pages: 29 - 29
Publication Date: 2015/11/23
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2015.10.303 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Valéria Costa-Hong
AU  - Henrique Muela
AU  - Allan Sales
AU  - Luiz Bortolotto*
PY  - 2015
DA  - 2015/11/23
TI  - P6.19 GENDER DIFFERENCES OF ARTERIAL STIFFNESS AND CENTRAL BLOOD PRESSURE IN PATIENTS WITH ARTERIAL HYPERTENSION AND THE INFLUENCE OF MENOPAUSE
JO  - Artery Research
SP  - 29
EP  - 29
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.303
DO  - 10.1016/j.artres.2015.10.303
ID  - Costa-Hong2015
ER  -

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