Artery Research

Volume 12, Issue C, December 2015, Pages 24 - 24

P5.20 MEASURE OF CHANGE IN CAROTID-RADIAL PULSE WAVE VELOCITY AFTER REACTIVE HYPERAEMIA

Authors
Hakim Khettab*1, Benjamin Nayagom1, Sandrine Millasseau2, Stephane Laurent1, Pierre Boutouyrie1
1HEGP, APHP, Paris, France
2Pulse Wave Consulting, St Leu la Foret, France
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.283How to use a DOI?
Abstract

The recognized reference method for endothelial function assessment is brachial artery diameter echo-tracking during flow mediated dilation (FMD) induced by reactive hyperaemia (RH). From the Mons-Korteweg equation, FMD should also reduce upper limb pulse wave velocity (PWV). The aim of our study was to compare echo-tracking FMD with PWV changes after RH.

Brachial diameter was assessed by echo-tracking (MyLAb 70, Easote, Italy) before and after 7 min of ischemia induced by inflating a cuff on the right wirst 50mmHg above subject’s systolic blood pressure. Carotid-left radial and carotid-right radial PWVs were also simultaneously measured with Complior Analyse (Alam Medical, France) at baseline (in triplicate), 30sec, 1, 3 and 5 min end of ischemia.

Measurements were performed in 15 healthy subjects (10M/5F, 31±11 yrs). Maximum PWV changes happened 1min after cuff deflation in the ischemic arm (ΔPWV=2,1±1,4m/s, p<0,001) while changes in the control arm were non-significant.

Time after deflation ΔPWV ischemic arm ΔPWV control arm
30sec −0,6 ± 0,6 −0,2 ± 1,0
1min −2,1 ± 1,4 * −0,1 ± 1,1
3min −1,9 ± 1,4 * −0,1 ± 1,2
5min −1,7 ± 1,3 −0,7 ± 2,5
*

p<0,001

The maximal change in arterial diameter post-RH was 5,1±4,7%. There was no correlation between diameter change and ΔPWV (R=0,03, p=0,91).

While the use carotid-radial PWV seems promising to track changes post RH, further studies are needed to better understand this phenomena which is not related to diameter change.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
12 - C
Pages
24 - 24
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.283How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Hakim Khettab*
AU  - Benjamin Nayagom
AU  - Sandrine Millasseau
AU  - Stephane Laurent
AU  - Pierre Boutouyrie
PY  - 2015
DA  - 2015/11/23
TI  - P5.20 MEASURE OF CHANGE IN CAROTID-RADIAL PULSE WAVE VELOCITY AFTER REACTIVE HYPERAEMIA
JO  - Artery Research
SP  - 24
EP  - 24
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.283
DO  - 10.1016/j.artres.2015.10.283
ID  - Khettab*2015
ER  -