P5.10 CHANGES IN MECHANICAL PROPERTIES OF FEMORAL ARTERY WALLS IN PIG MODEL OF ARTERIOSCLEROSIS

DOI

10.1016/j.artres.2015.10.275How to use a DOI?

Abstract

Arteriosclertic lesions leading to increased stiffnes of the walls. The goal of the research was to estimate changes in the mechanical properties of femoral artery in swine with experimentally induced arteriosclerotic changes by western type diet.

Methods: 32 white female pigs (40 kg), were divided into 3 groups: 1) 12 control pigs 2) 10 “diet” pigs fed a “western diet” 3) 10 pigs “regression” – fed a western diet for 9 months and then a standard diet for 3 months. Femoral arteries samples were stained HE method for histopathology, were tested for collagen and elastin content and mechanical properties. Arterioscleraotic changes were classified using 8 class scale (Stary et all. 2000). Mechanical test were conducted using Synergie 100 machine with force sensor MTS (mesurement range 0÷500 N). Thickness of artery wessels was measured by mikroskope SteREO Discovery V20 (Zeiss). Data were analysed statistically using the Statistica 10.0 software.

Results: 2 pigs in Diet group and 4 pigs in Regression group have arteriosclerotic plaque I and II grades. Mechanical indexes: σL Lagrangian stresses, ε Green strain, σ Cauchy stress, ES secant module and Et tangent modulus were not changed.

Conclusion: Despite presence of arteriosclerotic leasions iduced by feeding swine of western type diet, we not seen significant differences in mechanical properties of femoral artery in comparison to standard fed pigs.

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TY  - JOUR
AU  - Robert Pasławski
PY  - 2015
DA  - 2015/11/23
TI  - P5.10 CHANGES IN MECHANICAL PROPERTIES OF FEMORAL ARTERY WALLS IN PIG MODEL OF ARTERIOSCLEROSIS
JO  - Artery Research
SP  - 22
EP  - 22
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.275
DO  - 10.1016/j.artres.2015.10.275
ID  - Pasławski2015
ER  -