Artery Research

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Volume 12, Issue C, December 2015, Pages 19 - 20

P4.19 CARDIOVASCULAR RISK FACTORS AND LEFT VENTRICULAR HYPERTROPHY IN CHILDREN WITH CHRONIC KIDNEY DISEASE

Authors
Dorota Drozdz*1, Przemko Kwinta2, Zbigniew Kordon3, Katarzyna Zachwieja1, Monika Miklaszewska1, Krystyna Sztefko4, Andrzej Rudzinski3, Jacek Antoni Pietrzyk1
1Dialysis Unit, Jagiellonian University Medical College, Krakow, Poland
2Dpt. of Pediatrics, Jagiellonian University Medical College, Krakow, Poland
3Dpt. of Pediatric Cardiology, Jagiellonian University Medical College, Krakow, Poland
4Dpt. of Clin. Biochemistry, Jagiellonian University Medical College, Krakow, Poland
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.263How to use a DOI?
Abstract

Cardiovascular diseases are substantial causes of mortality among patients with chronic kidney disease (CKD). The aim of the study was an assessment of the impact of cardiovascular risk factors on left ventricular hypertrophy (LVH) in children with CKD.

Material and methods: The study was conducted in a group of 71 children with mean age 11 years and CKD stage 1 to 5. Serum cystatin C, albumin levels, and lipids profile were measured. Ambulatory blood pressure measurements and echocardiography were performed.

Results: LVH was detected in 34 out of 71 children. In children with LVH, significantly higher values of BP were observed in 24-hour measurements: systolic (119 vs. 109 mm Hg; p=0.002), diastolic BP (73 vs. 65 mm Hg; p=0.009) and MAP (89 vs. 81 mm Hg, p=0.004). These significantly higher BP values were observed within day and night. Increased cholesterol level was found in 25, LDL in 12, TGL in 28, and a decreased HDL in 20 children.

In children with LVH higher BMI (18.6 vs. 16.7 kg/m2;p=0.039) and lower albumin (41.5 vs. 45.4 g/l; p=0.013), HDL (1.14 vs. 1.5 mmol/l; p=0.001) and Ca levels (2.36 vs. 2.47 mmol/l; p=0.03) were found. Obesity and low HDL level were independent LVH risk factors. The results indicate a 3-fold increase in the risk of LVH in children with hypertension (OR 3.18, p=0.045), rising up when 2-3 risk factors were present (OR 6, p=0.015).

Conclusions: Hypertension, a decreased HDL cholesterol level and overhydration have significant impact on the development of LVH in CKD children.

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<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
12 - C
Pages
19 - 20
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.263How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Dorota Drozdz*
AU  - Przemko Kwinta
AU  - Zbigniew Kordon
AU  - Katarzyna Zachwieja
AU  - Monika Miklaszewska
AU  - Krystyna Sztefko
AU  - Andrzej Rudzinski
AU  - Jacek Antoni Pietrzyk
PY  - 2015
DA  - 2015/11/23
TI  - P4.19 CARDIOVASCULAR RISK FACTORS AND LEFT VENTRICULAR HYPERTROPHY IN CHILDREN WITH CHRONIC KIDNEY DISEASE
JO  - Artery Research
SP  - 19
EP  - 20
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.263
DO  - 10.1016/j.artres.2015.10.263
ID  - Drozdz*2015
ER  -