P4.8 ASSOCIATIONS OF MID-LIFE CARDIOVASCULAR RISK FACTORS WITH LATER LIFE COGNITIVE FUNCTION

DOI

10.1016/j.artres.2015.10.252How to use a DOI?

Abstract

Background: Mid-life cardiovascular risk factors may be detrimental to cognitive function in later life; however results are inconsistent. We investigated the impact of mid-life blood pressure, glucose, cholesterol and obesity on cognitive function.

Methods: In a community based sample aged 49.6±6years: waist-to-hip ratio (WHR), fasting blood glucose, HDL cholesterol and blood pressure were measured. 20 years later 1284 of these individuals underwent cognitive function testing to assess global function, executive function, memory and attention. Data are β±SE, ^*p<0.05, ^**p<0.01.

Results: After adjusting for age, sex, ethnicity, years of education and smoking no associations were found between cognitive function and mid-life glucose or blood pressure measures. Lower mid-life WHR and higher HDL cholesterol levels were significantly associated with better scores in all cognitive domains. Per unit increase in WHR: Global function −1.45±0.3^**; Executive function −1.82±0.3^**; Memory −1.27±0.3^** and Attention −1.23±0.03^**. Per mmol/L increase in HDL: Global function 0.19±0.06^**; Executive function 0.13±0.06^**; Memory 0.14±0.06^** and Attention 0.17±0.05^*. These associations remained after further adjustment for current concomitant risk factors: diabetes, hypertension, previous stroke, coronary artery disease and current WHR/ HDL (WHR: Global function −1.05±0.4^**; Executive function −2.2±0.4^**; Memory −1.1±0.4^** and Attention −1.15±0.4^**. HDL: Global function 0.20±0.07^**; Executive function 0.15±0.07^**; Memory 0.19±0.07^** and Attention 0.15±0.07^*).

Discussion: Elevated WHR and lower HDL cholesterol in mid-life are significant risk factors for cognitive decline 20 years later. These mid-life risk factors have effects independent of current risk factors and may be important targets for prevention of cognitive decline in later life.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Chloe Park*
AU  - Therese Tillin
AU  - Robert Stewart
AU  - Nish Chaturvedi
AU  - Alun Hughes
PY  - 2015
DA  - 2015/11/23
TI  - P4.8 ASSOCIATIONS OF MID-LIFE CARDIOVASCULAR RISK FACTORS WITH LATER LIFE COGNITIVE FUNCTION
JO  - Artery Research
SP  - 17
EP  - 17
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.252
DO  - 10.1016/j.artres.2015.10.252
ID  - Park*2015
ER  -