P4.5 VASCULAR HEALTH ASSESSMENT OF THE HYPERTENSIVE PATIENTS (VASOTENS) REGISTRY: RATIONALE, DESIGN AND METHODS OF AN INTERNATIONAL REGISTRY FOR AMBULATORY BLOOD PRESSURE AND ARTERIAL STIFFNESS TELEMONITORING
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Background: Ambulatory (A) blood pressure (BP), central BP and pulse wave velocity (PWV) are parameters recommended by hypertension guidelines for estimating BP control and vascular impairment. Recent advances in technology made available devices allowing combined non-invasive estimation of these parameters over the 24-h during ABPM. However, at present, there is limited evidence on the usefulness of such an approach for routine hypertension management.
Objective: We recently launched an investigator-initiated, international, multicenter, observational, prospective study aiming at: i) evaluating non-invasive 24-h ABP and arterial stiffness estimates (through 24-h pulse wave analysis, PWA) in hypertensive subjects; ii) assessing the changes in estimates following treatment; iii) weighing the impact of 24-h PWA on target organ damage and cardiovascular prognosis; iv) assessing the relationship between arterial stiffness, BP absolute level and variability, and prognosis.
Methods: Approximately 2000 subjects, referred to 20 hypertension clinics for routine diagnostic evaluation and follow-up of hypertension, will be recruited. Data collection will include ABPM, performed with a device allowing simultaneous non-invasive assessment of BP and arterial stiffness (BPLab), and clinical data (including cardiovascular outcomes). A web-based telemedicine platform will be used for data collection. Subjects will visit the centers at 6-12 month intervals. First follow-up results are expected to be available in the next 2-years.
Conclusions: The results of the VASOTENS Registry will help defining the normalcy thresholds for current and future indices derived from 24-h PWA, according to outcome data. They will also provide supporting evidence for the inclusion of such evaluation in recommendations on hypertension management.
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TY - JOUR AU - Stefano Omboni* AU - Igor N. Posokhov AU - Gianfranco Parati AU - Anatoli Rogoza AU - Alberto Avolio AU - Ernesto Cardona Muñoz AU - Lorenzo Ghiadoni AU - Vladimir Gorbunov AU - Elena Grigoricheva AU - Alexandra Konradi AU - Viktoria Korneva AU - Yulia Kotovskaya AU - Natalya Kulikova AU - Maria Lorenza Muiesan AU - Giuseppe Mulè AU - Iana Orlova AU - Carmine Savoia AU - Giuseppe Schillaci AU - Parounak Zelveian AU - Elena Zheleznyak PY - 2015 DA - 2015/11/23 TI - P4.5 VASCULAR HEALTH ASSESSMENT OF THE HYPERTENSIVE PATIENTS (VASOTENS) REGISTRY: RATIONALE, DESIGN AND METHODS OF AN INTERNATIONAL REGISTRY FOR AMBULATORY BLOOD PRESSURE AND ARTERIAL STIFFNESS TELEMONITORING JO - Artery Research SP - 16 EP - 16 VL - 12 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2015.10.249 DO - 10.1016/j.artres.2015.10.249 ID - Omboni*2015 ER -