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Volume 12, Issue C, December 2015, Pages 18 - 18

P4.13 HERITABILITY AND OTHER DETERMINANTS OF LEFT VENTRICULAR DIASTOLIC FUNCTION IN THE FAMILY-BASED POPULATION STUDY

Authors
M. Kloch-Badełek*2, V. Tikhonoff4, L. Thijs1, W. Sakiewicz3, K. Stolarz-Skrzypek2, K. Narkiewicz3, J. Staessen1, T. Kuznetsova1, K. Kawecka-Jaszcz2, D. Czarnecka2
1Studies Coordinating Centre, Division of Hypertension, University of Leuven, Leuven, Belgium
2The First Department of Cardiology and Hypertension, Cracow, Poland
3Hypertension Unit, Department of Hypertension and Diabetology, Medical University of Gdansk Gdansk, Poland
4The Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.257How to use a DOI?
Abstract

Background: Understanding to what extent genetic factors influence diastolic Doppler indexes is an important issue in view of the relation of left ventricular (LV) diastolic dysfunction with outcome. We, therefore, investigated in nuclear families recruited from the general population the heritability of LV diastolic traits and the composite diastolic score.

Methods and results: A random sample of 316 nuclear families (452 parents and 600 offspring, mean age, 58.5 and 33.3 years) was recruited in Belgium, Poland, Italy and Russia. We measured transmitral early and late diastolic velocities (E and A) by pulsed wave Doppler, and mitral annular velocities (E′ and A′) by tissue Doppler. Using principle component analysis, we summarized 5 Doppler indexes – namely, E, A, E′ and A′ velocities, and E/E′ – into a single diastolic score. To calculate the heritability of diastolic indexes, we used (1) the regression slope of offspring on mid-parent residual values, (2) variance decomposition in siblings. The parent-offspring concordances of all diastolic indexes were significant and ranged from 0.17 for A (P=0.009) to 0.42 for E′ (P<0.0001). In variance decomposition analyses in sibships, the abovementioned traits with adjustment for covariables had moderate heritability in a range of 0.12-0.31 (P≤0.01). Among the parent-offspring pairs and sibships, the heritability estimates of the composite diastolic score were 0.39 and 0.27, respectively (P<0.0001).

Conclusions: Our study demonstrated moderate heritability of various indexes reflecting LV diastolic function in nuclear families. The observation highlights the necessity of further research into the genes that affect LV diastolic function.

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<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
12 - C
Pages
18 - 18
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.257How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - M. Kloch-Badełek*
AU  - V. Tikhonoff
AU  - L. Thijs
AU  - W. Sakiewicz
AU  - K. Stolarz-Skrzypek
AU  - K. Narkiewicz
AU  - J. Staessen
AU  - T. Kuznetsova
AU  - K. Kawecka-Jaszcz
AU  - D. Czarnecka
PY  - 2015
DA  - 2015/11/23
TI  - P4.13 HERITABILITY AND OTHER DETERMINANTS OF LEFT VENTRICULAR DIASTOLIC FUNCTION IN THE FAMILY-BASED POPULATION STUDY
JO  - Artery Research
SP  - 18
EP  - 18
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.257
DO  - 10.1016/j.artres.2015.10.257
ID  - Kloch-Badełek*2015
ER  -