P3.9 PROGRESSION OF ARTERIAL STIFFNESS AND VASCULAR LESIONS ACCORDING TO THE DEGREE OF GLYCEMIC ABNORMALITIES. A WARNING IN PATIENTS WITH METABOLIC SYNDROME

DOI

10.1016/j.artres.2015.10.234How to use a DOI?

Abstract

Introduction: Metabolic Syndrome (MS), is postulated as intermediate stage in the way to overt DBT, and probably the degree of vascular compromise in this stage could explain the higher proportion of CV complications in diabetics. If so, it should deserve an intensive prevention in MS to reduce DBT complications.

Objective: To compare the vascular patterns in MS and DBT patients (p.).

Methods: From our Vascular Lab database (2007–2012) we selected 3297 p. in primary prevention, first evaluated with data of central BP (Arteriograph), IMT, plaques in carotid and femoral arteries (P), PWV (Complior) and forearm endothelial test. We compared 215 control (C) p. (normal BP, NO risk factors, evident CV disease or drugs), 91 p. with MS according to IDF (2014) and 193 type 2 diabetic p. (DBT2).

Results: DBT2 were older, less men and closer with MS p. in terms of BP, HR, PP, CAoP and AIX. Vascular patterns were quite similar between MS and DBT2 and significantly different from C. MS and DBT2 showed a higher proportion of P, atherosclerotic burden and PWV than (C) and also the clinical score of risk (FRS) and the severity of vascular disease score. DBT2 and MS were almost similar.

Conclusion: The progression of vascular disease from the early MS to DBT2 could explain the higher degree of complications in DBT2. These findings suggest the usefulness of vascular evaluation of MS patients to guide and intensify preventive measures to improve the prognosis of DBT2 patients.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Pedro Forcada*
AU  - Carlos Castellaro
AU  - Jorge Chiabaut
AU  - Sergio Gonzalez
AU  - Carol Kotliar
AU  - Sebastian Obregon
PY  - 2015
DA  - 2015/11/23
TI  - P3.9 PROGRESSION OF ARTERIAL STIFFNESS AND VASCULAR LESIONS ACCORDING TO THE DEGREE OF GLYCEMIC ABNORMALITIES. A WARNING IN PATIENTS WITH METABOLIC SYNDROME
JO  - Artery Research
SP  - 12
EP  - 13
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.234
DO  - 10.1016/j.artres.2015.10.234
ID  - Forcada*2015
ER  -