P1.14 ANALYSIS OF LEFT VENTRICULAR FILLING DYNAMICS

DOI

10.1016/j.artres.2015.10.206How to use a DOI?

Abstract

Diastolic filling of the left ventricle (LV) occurs in two phases, early and late filling. Early filling, manifest as the “E-wave”, is thought to be substantially due to diastolic suction (DS), a phenomenon where the LV aspirates blood and fills itself, independent of atrial activity. Late filling, resulting in the mitral flow “A-wave” is a result of left atrial contraction. Adequate filling of the LV is necessary to maintain normal heart function at rest and under stress. DS is thought to be an important mechanism in the efficiency of filling.

To study DS, we have invasively measured pressure and used cardiac MRI to evaluate cavitary volume and flow in an animal model to quantify different measures of DS under varied experimental conditions.

The amount of filling due to DS (VDS), determined by the change in volume between mitral valve opening and LV pressure minimum of the pressure-volume loop (Katz 1930), is related to the measured end systolic volume (ESV). As ESV decreases the VDS increases. The smaller the ESV, the larger the recoil energy of the LV as it relaxes towards resting volume. This contributes increased energy for the suction of blood into the ventricle in early filling.

Wave intensity analysis (the separation of forward and backwards waves and wave type) and intraventricular pressure gradients will also be considered in order to determine which best describes DS and whether they can be used together to better understand changes in filling dynamics under varied loading conditions.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Lindsay Burrowes*
AU  - Alessandro Satriano
AU  - Richard Thompson
AU  - Nigel Shrive
AU  - John Tyberg
PY  - 2015
DA  - 2015/11/23
TI  - P1.14 ANALYSIS OF LEFT VENTRICULAR FILLING DYNAMICS
JO  - Artery Research
SP  - 6
EP  - 6
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.206
DO  - 10.1016/j.artres.2015.10.206
ID  - Burrowes*2015
ER  -