CD2 CIRCADIAN BLOOD PRESSURE PROFILE AND TARGET ORGAN DAMAGE

DOI

10.1016/j.artres.2015.10.189How to use a DOI?

Abstract

The 24-hour brachial ambulatory blood pressure measurement (ABPM) has the unique ability to provide information on 24-hour averaged blood pressure (BP), on nocturnal BP and day–night BP changes, as well as on 24-hour BP variability, which all provide independent prognostic information over that provided by office BP measurements. The clinical relevance of ABPM is clearly established in both treated and untreated hypertensive individuals. ABPM shows a stronger correlation with subclinical organ damage than office BP and is a significantly better predictor of cardiovascular events.

In the last two decades, several devices have been made available that aim at estimating noninvasively central systolic blood pressure, that is, pressure in the ascending aorta. Nowadays, due to new techniques development, it is also possible to perform 24-hour central ABPM. In our study, we presented the circadian central systolic BP profile and showed that central pressure values differ significantly from peripheral pressure values, not only in standard, office conditions but also during regular daytime activity as well as during nighttime hours. Moreover, systolic pressure amplification (i.e. the difference between systolic peripheral and central BP) appears to vary over a 24-hour period, and the main factor leading to a lower systolic pressure amplification at night is a nocturnal drop in the heart rate. Furthermore, we demonstrated that 24-central SBP is related to specific target organ damage, such as left ventricle mass index, left ventricle diastolic function, left atrial volume and intima-media thickness.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Agnieszka Bednarek
PY  - 2015
DA  - 2015/11/23
TI  - CD2 CIRCADIAN BLOOD PRESSURE PROFILE AND TARGET ORGAN DAMAGE
JO  - Artery Research
SP  - 1
EP  - 1
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.189
DO  - 10.1016/j.artres.2015.10.189
ID  - Bednarek2015
ER  -