Artery Research

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Volume 20, Issue C, December 2017, Pages 108 - 109

P191 AORTIC STIFFNESS AND INFLAMMATION IN INFLAMMATORY BOWEL DISEASES: AN INDIVIDUAL PARTICIPANT DATA META-ANALYSIS

Authors
Luca Zanoli1, Pierre Boutouyrie2, Pasquale Fatuzzo3, Kadir Ozturk4, Maria Cappello5, Eleni Theocharidou6, Pietro Castellino3, Stephane Laurent2
1Internal Medicine, School of Nephrology, University of Catania, Italy
2Department of Pharmacology, HEGP, AP-HP, INSERM U970, Italy
3Internal Medicine, University of Catania, Italy
4Department of Gastroenterology, Gulhane School of Medicine, Turkey
5Gastroenterology and Hepatology Section, DIBIMIS, University of Palermo, Italy
6Aristotle University of Thessaloniki, Greece
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.192How to use a DOI?
Abstract

Importance: The finding that aortic pulse wave velocity (aPWV) is increased may explain why patients with inflammatory bowel disease (IBD) have an increased cardiovascular risk despite the low prevalence of classic cardiovascular risk factors.

Objective: To determine why these patients have an increased aPWV.

Data sources: A systematic literature search for aPWV in IBD was performed using PubMed, Scopus, Web of Science, and Google Scholar databases.

Study selection: Inclusion criterion was peer-reviewed publications on clinical studies reporting original data.

Data extraction and synthesis: This study followed PRISMA-IPD 2015 guidelines. Data were provided for 4 cohorts in 3 countries (151 participants with ulcerative colitis [UC], 159 with Crohn disease [CD], and 227 controls). Using aPWV, cohort-specific z-scores were calculated after loge-transform and combined in meta-analysis to form pooled effects using a random- effects model.

Main outcome and measures: The aPWV, a reference measure of aortic stiffness, after adjusting for age, sex, mean blood pressure, known cardiovascular risk factors, and study of origin.

Results: The pooled z-score was 1.2 m/s. The aPWV was dependent on CD (β 0.80 z-score [1.0 m/s], 95% confidence interval 0.61–1.00 z-score, P < 0.001) and UC (β 0.69 z- score [0.8 m/s], 95% confidence interval 0.49–0.88 z-score, P < 0.001). In patients with IBD, the aPWV was dependent on disease duration (square root [years], β 0.15 z- score, 95% confidence interval 0.02–0.29 z-score, P = 0.03) and white blood cell count (Loge [billion cells/L], β 0.48 z-score, 95% confidence interval 0.12–0.84 z-score, P = 0.01) but not on cardiovascular risk factors and therapy.

Conclusions: The increased aPWV reported in this patient population is dependent on inflammation.

Open Access
This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
108 - 109
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.192How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Luca Zanoli
AU  - Pierre Boutouyrie
AU  - Pasquale Fatuzzo
AU  - Kadir Ozturk
AU  - Maria Cappello
AU  - Eleni Theocharidou
AU  - Pietro Castellino
AU  - Stephane Laurent
PY  - 2017
DA  - 2017/12/06
TI  - P191 AORTIC STIFFNESS AND INFLAMMATION IN INFLAMMATORY BOWEL DISEASES: AN INDIVIDUAL PARTICIPANT DATA META-ANALYSIS
JO  - Artery Research
SP  - 108
EP  - 109
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.192
DO  - 10.1016/j.artres.2017.10.192
ID  - Zanoli2017
ER  -