Artery Research

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Volume 20, Issue C, December 2017, Pages 106 - 106

P183 INCREASED ARTERIAL STIFFNESS IS ASSOCIATED WITH POORER LEFT VENTRICULAR STRUCTURE AND FUNCTION IN ADOLESCENCE

Authors
Hannah Taylor1, Alun Hughes1, Marietta Charakida2, Nishi Chaturvedi1, George Davey- Smith3, John Deanfield2, Abigail Fraser3, Laura Howe3, Debbie Lawlor3, Chloe Park1
1Cardiometabolic Phenotyping Group, University College London, UK
2Vascular Physiology Unit, Institute of Cardiovascular Science, University College London, UK
3MRC Integrative Epidemiology Unit (IEU), University of Bristol, UK
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.184How to use a DOI?
Abstract

Introduction: Increased arterial stiffness (AS) in adults causes increased left ventricular (LV) afterload, putting additional strain on the heart. Long-term, this can lead to an adverse cardiovascular phenotype and AS has been found to be a determinant of CVD, independent of traditional cardiovascular risk factors. However, limited evidence exists for this association in children and adolescents.

Methods: 1625 young adults (age 17y; 46% male) from the Avon Longitudinal Study of Parents and Children (ALSPAC), a UK based birth cohort, underwent echocardiography and carotid-to-femoral pulse wave velocity (PWV) measures. Linear regression was used to investigate associations between PWV and LV structure and function, including LV mass, relative wall thickness (RWT), left atrial diameter (LAD), mitral inflow (E:A), midwall fractional shortening (MFS) and tissue Doppler peak systolic velocity (s′).

Results: Elevated PWV was associated with increased LV mass and RWT and inversely associated with E:A and MFS (Table 1). Adjustment for age and sex attenuated the association with LV mass. Further adjustment for body mass index (BMI), systolic blood pressure (SBP), alcohol, smoking and socioeconomic status (SES) attenuated the association with RWT, whilst the associations with E:A and MFS remained.

Unadjusted Age and sex adjusted Age, sex, BMI, SBP, alcohol, smoking, SES adjusted
Coefficient±SE P value Coefficient±SE P value Coefficient±SE P value
LV mass2.7 (g/m2.7) 0.55±0.21 0.009 −0.066±0.225 0.768 −0.123±0.225 0.584
RWT 0.007±0.002 <0.001 0.008±0.002 <0.001 0.005±0.00 0.069
LAD (cm) −0.004±0.015 0.784 −0.017±0.015 0.268 −0.010±0.016 0.516
E:A −0.054±0.014 <0.001 −0.073±0.015 <0.001 −0.067±0.019 <0.001
MFS (%) −0.40±0.079 <0.001 −0.246±0.085 0.004 −0.232±0.1 0.022
s′ (cm/s) 0.078±0.05 0.138 0.004±0.057 0.937 −0.038±0.067 0.567

Conclusion: Increased AS is already associated with poorer measures of LV structure and function in adolescence. Adjustment for potential confounders did not substantially attenuate these associations with LV function.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
106 - 106
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.184How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Hannah Taylor
AU  - Alun Hughes
AU  - Marietta Charakida
AU  - Nishi Chaturvedi
AU  - George Davey- Smith
AU  - John Deanfield
AU  - Abigail Fraser
AU  - Laura Howe
AU  - Debbie Lawlor
AU  - Chloe Park
PY  - 2017
DA  - 2017/12/06
TI  - P183 INCREASED ARTERIAL STIFFNESS IS ASSOCIATED WITH POORER LEFT VENTRICULAR STRUCTURE AND FUNCTION IN ADOLESCENCE
JO  - Artery Research
SP  - 106
EP  - 106
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.184
DO  - 10.1016/j.artres.2017.10.184
ID  - Taylor2017
ER  -