Artery Research

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Volume 20, Issue C, December 2017, Pages 100 - 101

P25 VASCULAR AGING IS ASSOCIATED WITH THE SEVERITY OF CEREBRAL WHITE MATTER LESION LOAD

Authors
Lisanne Tap1, Annegreet van Opbroek2, Wiro Niessen2, 3, Marion Smits4, Francesco Mattace- Raso1
1Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
2Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology & Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
3Imaging Physics, Applied Sciences, Delft University of Technology, Delft, The Netherlands
4Departments of Radiology & Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.166How to use a DOI?
Abstract

Background: Blood pressure (BP) levels and aortic stiffness are associated with the presence of cerebal small vessel disease, whereas little is known on the possible association of BP levels, aortic stiffness and the severity of cerebral small vessel disease. In a pilot study we investigated whether hemodynamic measures are associated with the presence and severity of cerebral white matter lesion load (WML).

Methods: Fazekas score was used to analyse WML on neuroimaging of 84 persons visiting the Outpatient Geriatric Clinic; an automatic white matter hyperintensity segmentation method was used in a subgroup of 44 MRI-scans to determine the exact volume of WML. Aortic stiffness, measured as aortic pulse wave velocity (aPWV), and BP levels were non-invasively measured by Mobil-o-Graph.

Results: Mean age was 76.6 years. Age was correlated with aPWV (r2 = 0.722, p < 0.001) and volume of WML (r2 = 0.296, p < 0.001). aPWV and central pulse pressure levels (cPP) increased with increasing Fazekas score (p for trend <0.001 and 0.043, respectively). After adjustment, higher aPWV was observed in the highest Fazekas category compared to the lowest, although not statically significant (p for trend = 0.151). Both cPP and aPWV were associated with WML volumes in univariate analyses (lnβ 0.298, p = 0.055 and lnβ 0.541, p < 0.001, respectively); in multivariate analyses, estimates were less consistent.

Conclusion: Increased pulse pressure and increased aortic stiffness were associated with the severity of WML, assessed with both Fazekas score and a quantative hyperintenstity segmentation method. Age is highly associated with aortic stiffness and cerebral small vessel disease.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
100 - 101
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.166How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Lisanne Tap
AU  - Annegreet van Opbroek
AU  - Wiro Niessen
AU  - Marion Smits
AU  - Francesco Mattace- Raso
PY  - 2017
DA  - 2017/12/06
TI  - P25 VASCULAR AGING IS ASSOCIATED WITH THE SEVERITY OF CEREBRAL WHITE MATTER LESION LOAD
JO  - Artery Research
SP  - 100
EP  - 101
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.166
DO  - 10.1016/j.artres.2017.10.166
ID  - Tap2017
ER  -