P156 DURATION OF DIABETES MELLITUS IS A SIGNIFICANT PREDICTOR OF ARTERIAL STIFFNESS IN PATIENTS WITH ARTERIAL HYPERTENSION AND TYPE 2 DIABETES MELLITUS

DOI

10.1016/j.artres.2017.10.177How to use a DOI?

Abstract

Background: Diabetic complications increase with disease duration but little is known about the relationships between aortic stiffness and diabetes duration.

Aim: to assess associations of diabetes mellitus (DM) duration and parameters of arterial stiffness in patients with arterial hypertension (AH) and T2DM.

Methods: 90 patients with AH and T2DM were included (39%males, mean age63,8±11,6 years, 44%smokers). Mean office BP was 146±23/86±10 mmHg. All patients received combined AHT, target BP < 140/85 mmHg was achieved in 52,7% of patients. Median duration of DM was 8,5 years (IQR 2; 13 years), mean glucose was 8,0±2,4 mmol/l, mean HbA1c 9,2±2,0%. BP was measured with a validated oscillometric device.

Parameters of arterial stiffness were assessed by applanation tonometry, cardio- ankle vascular index (CAVI) and vascular age were measured (VaSera 1500). p < 0,05 was considered significant.

Results: Mean central BP was 132±18/79±12 mmHg, mean cfPWV–10,5±2,4 m/s, mean R- CAVI-8,8±1,9, L-CAVI-8,9±1,8. Further analysis was performed in subgroups according to tertiles of DM duration (G1 < 4 years (n = 31), G2–4-10 years (n = 30), G3 > 10 years (n = 29)). Patients in G3 were older (69,5±11,1 vs 62,1±11,2 vs 60,0±10,8 years), had higher vascular age (73,8±9,0 vs 68,6±11,8 vs 64,5±13,4 years) and R- CAVI (9,3±1,9 vs 9,0±1,8 vs 8,1±1,9); p < 0,05 for trend. Patients from G3 and G2 had the highest level of cfPWV compared to G1 (11,0±2,0 and 11,4±2,4 vs 9,1±2,4 m/s, p = 0,0009). There were significant correlations between duration of DM and age (r = 0,35), vascular age (r = 0,30), creatinine (r = 0,23), cfPWV (r = 0,34), and R-CAVI (r = 0,3). Only age and DM duration were predictors of PWV increase (β = 0,3, p = 0,02 and β = 0,2, p = 0,04, respectively).

Conclusions: In diabetic patients, aortic stiffness is strictly correlated with diabetes duration, independently of blood pressure level and diabetes control.

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TY  - JOUR
AU  - Elena Troitskaya
AU  - Ekaterina Starostina
AU  - Zhanna Kobalava
PY  - 2017
DA  - 2017/12/06
TI  - P156 DURATION OF DIABETES MELLITUS IS A SIGNIFICANT PREDICTOR OF ARTERIAL STIFFNESS IN PATIENTS WITH ARTERIAL HYPERTENSION AND TYPE 2 DIABETES MELLITUS
JO  - Artery Research
SP  - 104
EP  - 104
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.177
DO  - 10.1016/j.artres.2017.10.177
ID  - Troitskaya2017
ER  -