Artery Research

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Volume 20, Issue C, December 2017, Pages 98 - 98

P19 INFLUENCE OF BRACHIAL ARTERY STIFFNESS ON FLOW-MEDIATED DILATATION IN HEALTHY YOUNG AND OLDER POPULATIONS

Authors
Kunihiko Aizawa1, Sara Sbragi2, Alessandro Ramalli3, Piero Tortoli3, Francesco Casanova1, Carmela Morizzo2, Clare Thorn1, Angela Shore1, Phillip Gates1, Carlo Palombo2
1Diabetes and Vascular Medicine Research Centre, NIHR Exeter Clinical Research Facility, University of Exeter Medical School, UK
2Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa, Italy
3Department of Information Engineering, University of Florence, Florence, Italy
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.160How to use a DOI?
Abstract

Background: Increased brachial artery (BA) stiffness has previously been shown to affect the magnitude of FMD response in patients with high cardiovascular risk. However, it is unclear whether increased BA stiffness explains the diminished FMD response typically observed in a healthy older population. We determined whether BA stiffness would be greater in the older than the young population, and whether it would influence FMD responses in the former.

Methods: Data from 33 young (YNG: 27.5±4.9yrs) and 33 older (OLD: 64.9±3.6yrs) individuals were analysed. FMD was assessed with reactive hyperaemia using Ultrasound Advanced Open Platform (ULA-OP). All acquired raw data were post-processed using custom-designed software to obtain parameters of WSR and diameter. BA stiffness was calculated from BA systolic and diastolic diameters with simultaneous contra-lateral BA blood pressure measurements, and was expressed as pulse wave velocity (PWV) and β-stiffness index.

Results: Both PWV [YNG: 9.5(8.7−10.3) vs OLD: 9.4(8.6–10.2) m/s] and β-stiffness index [YNG: 17.5(14.7–20.2) vs OLD: 16.7(13.9–19.4) au] were similar between populations. In YNG, there was no association between BA stiffness parameters and diameter changes obtained during FMD and nitroglycerin-mediated dilatation assessments. The association was also absent in OLD during either assessment.

Conclusions: These results demonstrate that BA stiffness is not increased in the healthy older population compared to the young counterpart. Furthermore, there is no association between BA stiffness parameters and the FMD response in either population, suggesting that BA stiffness may not influence BA vasodilatory response in healthy adults.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
98 - 98
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.160How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Kunihiko Aizawa
AU  - Sara Sbragi
AU  - Alessandro Ramalli
AU  - Piero Tortoli
AU  - Francesco Casanova
AU  - Carmela Morizzo
AU  - Clare Thorn
AU  - Angela Shore
AU  - Phillip Gates
AU  - Carlo Palombo
PY  - 2017
DA  - 2017/12/06
TI  - P19 INFLUENCE OF BRACHIAL ARTERY STIFFNESS ON FLOW-MEDIATED DILATATION IN HEALTHY YOUNG AND OLDER POPULATIONS
JO  - Artery Research
SP  - 98
EP  - 98
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.160
DO  - 10.1016/j.artres.2017.10.160
ID  - Aizawa2017
ER  -