Artery Research

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Volume 20, Issue C, December 2017, Pages 90 - 91

P107 OSCILLOMETRIC MEASUREMENT OF 24-HOUR PULSE WAVE VELOCITY PREDICTS ALL- CAUSE MORTALITY IN PATIENTS WITH END-STAGE RENAL DISEASE: THE ISAR-STUDY

Authors
Julia Matschkal1, Christopher C. Mayer2, Siegfried Wassertheurer2, Georg Lorenz1, Susanne Angermann1, Stephan Kemmner1, Matthias Braunisch1, Roman Günthner1, Bernhard Haller3, Marcus Baumann4, Uwe Heemann1, Christoph Schmaderer1
1Department of Nephrology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
2Center for Health & Bioresources, AIT Austrian Institute of Technology, Vienna, Austria
3Institute for Medical Statistics and Epidemiology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
4Department of Nephrology, Klinikum Ansbach, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen-Nuremberg, Germany
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.138How to use a DOI?
Abstract

Objectives: Mortality rate in end-stage renal disease (ESRD) are still at a high level. Sarafidis et al. showed the predictive value of 48h PWV in patients undergoing hemodialysis [1], although recent studies using office measurement showed controversial predictive results. Aim of the present study was to confirm the predictive value of a novel oscillometric measurement of pulse wave velocity on mortality in an elderly cohort of patients with ESRD.

Methods: The ISAR study is a prospective and longitudinal study targeting patients with ESRD undergoing hemodialysis. Oscillometric measurement of 24-hour PWV was performed at baseline. Survival analysis included Kaplan-Meier analysis, logrank test and Cox regression.

Results: A total of 350 patients had a median age of 69.3 [55.8; 77.3] years. Mean PWV was 9.6 (2.2) m/s and 120 patients died during the mean follow-up of 45 months. PWV was significantly higher in the deceased (10.6 +/− 1.9 m/s) than in surviving patients (9.0 +/− 2.2 m/s). Kaplan-Meier analysis showed differences in dichotomized PWV (cut-off 10 m/s [2]; Logrank test: p = 0.001). For results of univariate Cox regression, see Figure. Adjusted Cox regression analysis showed a significant risk prediction for all-cause mortality (HR 2.322; p = 0.011). Patients older than 50 years showed even higher predictive values (HR 2.442; p = 0.008) as well as patients with PWV values of at least 10 m/s (HR 3.300; p = 0.006).

Figure.

Univariate hazard-ratios and their 95% confidence intervals for continuous PWV and PWV quartiles (Q1 as reference; ** p = 0.002; *** p < 0.001). Ql: <=7.92 m/s; Q2: 7.92–9.83 m/s; Q3: 9.83–11.23 m/s; Q4: >11.23 m/s.

Conclusion: Oscillometric measurement of 24-hour pulse wave velocity is a simple and valid method and has an additional predictive value for all-cause mortality in elderly patients with end-stage renal disease.

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<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
20 - C
Pages
90 - 91
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.138How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

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risenwbib
TY  - JOUR
AU  - Julia Matschkal
AU  - Christopher C. Mayer
AU  - Siegfried Wassertheurer
AU  - Georg Lorenz
AU  - Susanne Angermann
AU  - Stephan Kemmner
AU  - Matthias Braunisch
AU  - Roman Günthner
AU  - Bernhard Haller
AU  - Marcus Baumann
AU  - Uwe Heemann
AU  - Christoph Schmaderer
PY  - 2017
DA  - 2017/12/06
TI  - P107 OSCILLOMETRIC MEASUREMENT OF 24-HOUR PULSE WAVE VELOCITY PREDICTS ALL- CAUSE MORTALITY IN PATIENTS WITH END-STAGE RENAL DISEASE: THE ISAR-STUDY
JO  - Artery Research
SP  - 90
EP  - 91
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.138
DO  - 10.1016/j.artres.2017.10.138
ID  - Matschkal2017
ER  -