P100 TRIAL OF EXERCISE TO PREVENT HYPERTENSION IN YOUNG ADULTS (TEPHRA): RATIONALE AND PROTOCOL

DOI

10.1016/j.artres.2017.10.136How to use a DOI?

Abstract

Background: Hypertension or pre-hypertension in young adults is unusual and more often linked with an adverse family or pregnancy history, such as preterm birth, than hypertension which develops later in life^1–4. Surprisingly, no trials have investigated whether lifestyle advice developed for blood pressure control in older adults is effective in these young populations⁵.

Methods: TEPHRA is a randomised control trial of a 16 week physical activity intervention including behaviour change and structured exercise in young adults with pre- and stage 1 hypertension. On-line recruitment is used with targeting to ensure inclusion of a proportion born preterm. Primary outcome is 24 hr ambulatory blood pressure at 4 months. Subjects undergo additional multimodal assessments including vascular stiffness, blood sampling, microvascular assessment, echocardiography, remote activity monitoring and multi-organ magnetic resonance imaging to identify potential predictors of blood pressure change.

Results: Recruitment started in April 2016 and currently (June 2017) 344 potential participants have been screened with 103 progressing to a baseline visit, of which 91 have been randomized. Two participants have completed their 12 month follow up. Recruitment is predicted to be completed by February 2018 with data reporting of four months outcomes in late 2018.

Conclusion: TEPHRA aims to deliver the most in-depth investigation to date on the effects of physical exercise on the cardiovascular system and health of young adults at risk of early hypertension and cardiovascular disease.

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TY  - JOUR
AU  - Afifah Mohamed
AU  - Odaro Huckstep
AU  - Wilby Williamson
AU  - Charlotte Herdman
AU  - Yvonne Kenworthy
AU  - Konstantina Spagou
AU  - Linda Arnold
AU  - Polly Whitworth
AU  - Ashley Verburg
AU  - Holger Burchert
AU  - Adam J. Lewandowski
AU  - Paul Leeson
PY  - 2017
DA  - 2017/12/06
TI  - P100 TRIAL OF EXERCISE TO PREVENT HYPERTENSION IN YOUNG ADULTS (TEPHRA): RATIONALE AND PROTOCOL
JO  - Artery Research
SP  - 89
EP  - 90
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.136
DO  - 10.1016/j.artres.2017.10.136
ID  - Mohamed2017
ER  -