P95 EFFECT OF CHRONIC INFLAMMATION INHIBITION WITH SALSALATE ON AORTIC STIFFNESS AND VASCULAR ENDOTHELIAL FUNCTION IN OLDER ADULTS: A RANDOMIZED CONTROLLED STUDY

Gary Pierce; Lyndsey DuBose; Amy Stroud; Nicholas Jensen; Lauren Wegman-Points; Seth Holwerda; William Haynes; Kaitlyn Dubishar; Jess Fiedorowicz

doi:10.1016/j.artres.2017.10.132

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Volume 20, Issue C, December 2017, Pages 88 - 89

P95 EFFECT OF CHRONIC INFLAMMATION INHIBITION WITH SALSALATE ON AORTIC STIFFNESS AND VASCULAR ENDOTHELIAL FUNCTION IN OLDER ADULTS: A RANDOMIZED CONTROLLED STUDY

Authors

Gary Pierce¹, Lyndsey DuBose¹, Amy Stroud¹, Nicholas Jensen¹, Lauren Wegman-Points¹, Seth Holwerda¹, William Haynes², Kaitlyn Dubishar¹, Jess Fiedorowicz³

¹Department of Health and Human Physiology, University of Iowa, Iowa City, USA

²Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City, USA

³Departments of Psychiatry, Internal Medicine and Epidemiology, University of Iowa, Iowa City, USA

Available Online 6 December 2017.

DOI: 10.1016/j.artres.2017.10.132 How to use a DOI?
Abstract: Chronic activation of the proinflammatory transcription factor nuclear factor kappa-B (NFkB) is linked to age-associated vascular dysfunction. Acute inhibition of NFkB with high-dose salsalate (>4g), a non-acetylated salicylate known to block NFkB activation, improves aortic stiffness and endothelial function in aged rodents and humans.

Therefore, we hypothesized that chronic salsalate therapy at the US FDA approved starting dose (3 g/day) would improve age-associated aortic stiffness and endothelial dysfunction in older adults. A total of 28 normotensive older adults (57.4±1.3 yrs; 11M/13F) were randomized to salsalate 3 g/day (n = 14) or placebo (n = 14) for 4 weeks and had assessments of aortic stiffness (carotid-femoral pulse wave velocity, CFPWV) and endothelial function (brachial artery flow-mediated dilation, FMD).

A group of 17 young adults (age 26±1 yrs) were not randomized. As expected, baseline CFPWV was higher (8.1±0.3 vs 5.3±0.2 m/sec, P < 0.01) and FMD was lower (3.4±0.8 vs. 5.9±1.0%, P = 0.03) in the older vs. young. In the older adults, neither FMD (SALS: 3.5±1.4 to 4.6±1.2%; PLAC: 3.4±1.2 to 2.5±1.3%, ANOVA P = 0.98) nor CFPWV (SALS: 8.1±0.5 to 8.4±0.6 m/sec; PLAC: 7.6±0.5 to 7.6±0.4 m/sec, ANOVA P = 0.41) was altered after 4 weeks of salsalate vs. placebo.

These data fail to demonstrate that chronic salsalate timproves age-associated aortic stiffness or endothelial dysfunction in older adults. Future studies should test longer duration therapy or more selective inflammatory inhibitors on vascular aging in humans.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 20 - C
Pages: 88 - 89
Publication Date: 2017/12/06
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2017.10.132 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Gary Pierce
AU  - Lyndsey DuBose
AU  - Amy Stroud
AU  - Nicholas Jensen
AU  - Lauren Wegman-Points
AU  - Seth Holwerda
AU  - William Haynes
AU  - Kaitlyn Dubishar
AU  - Jess Fiedorowicz
PY  - 2017
DA  - 2017/12/06
TI  - P95 EFFECT OF CHRONIC INFLAMMATION INHIBITION WITH SALSALATE ON AORTIC STIFFNESS AND VASCULAR ENDOTHELIAL FUNCTION IN OLDER ADULTS: A RANDOMIZED CONTROLLED STUDY
JO  - Artery Research
SP  - 88
EP  - 89
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.132
DO  - 10.1016/j.artres.2017.10.132
ID  - Pierce2017
ER  -

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