P94 DAPAGLIFLOZIN ACUTELY RESTORES ENDOTHELIAL DYSFUNCTION, REDUCES AORTIC STIFFNESS AND RENAL RESISTIVE INDEX IN TYPE 2 DIABETIC PATIENTS: A PILOT STUDY

DOI

10.1016/j.artres.2017.10.131How to use a DOI?

Abstract

Objective: Sodium-glucose co-transporter-2 inhibitors reduce blood pressure and renal and cardiovascular events in patients with type 2 diabetes through not fully elucidated mechanisms. Aim of this study was to investigate whether dapagliflozin is able to acutely modify systemic and renal vascular function.

Methods: Neuro-hormonal and vascular variables, together with 24h-urinary sodium, glucose, isoprostanes, diuresis and free-water clearance, were assessed before and after a 2- day treatment with dapagliflozin 10 mg/die in 16 type 2 diabetic patients. Brachial artery endothelium-dependent and independent vasodilation (by flow-mediated dilation) and pulse wave velocity were assessed. Renal resistive index was obtained at rest and after glyceril trinitrate administration.

Results: Dapagliflozin decreased systolic blood pressure and urinary isoprostanes and induced an increase in 24h-diuresis, 24h-urinary glucose and serum magnesium; 24h-urinary Na and fasting blood glucose were unchanged; serum magnesium slightly increased. Flow-mediated dilation was significantly increased (2.8±2.2 to 4.0±2.1%, p < 0.05), and pulse-wave-velocity was reduced (10.1±1.6 to 8.9±1.6 m/s, p < 0.05), even after correction for mean blood pressure. Renal resistive index was reduced (0.62±0.04 to 0.59±0.05, p < 0.05), as well as its response to nitrates.

Conclusions: An acute treatment with Dapagliflozin significantly improves systemic endothelial function, arterial stiffness and renal resistive index; this effect is independent of changes in blood pressure and occurs in the presence of stable natriuresis, suggesting a fast, direct beneficial effect on the vasculature, possibly mediated by oxidative stress reduction.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Rosa Maria Bruno
AU  - Livia Giannini
AU  - Marta Seghieri
AU  - Edoardo Vitolo
AU  - Stefano Taddei
AU  - Lorenzo Ghiadoni
AU  - Anna Solini
PY  - 2017
DA  - 2017/12/06
TI  - P94 DAPAGLIFLOZIN ACUTELY RESTORES ENDOTHELIAL DYSFUNCTION, REDUCES AORTIC STIFFNESS AND RENAL RESISTIVE INDEX IN TYPE 2 DIABETIC PATIENTS: A PILOT STUDY
JO  - Artery Research
SP  - 88
EP  - 88
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.131
DO  - 10.1016/j.artres.2017.10.131
ID  - Bruno2017
ER  -