P131 DETERMINANTS OF A NEW, NON-INVASIVE INDEX OF VENTRICULAR-ARTERIAL COUPLING AND MYOCARDIAL PERFORMANCE IN A GENERAL POPULATION SAMPLE

DOI

10.1016/j.artres.2017.10.113How to use a DOI?

Abstract

Background: The interaction between the heart and arteries (i.e. ventricular-arterial coupling, VAC) is a key determinant of cardiovascular performance. As such, VAC indexes might reflect the interplay between arterial stiffness and left ventricular (LV) dysfunction. In a community-based sample, we assessed the determinants of a new, non-invasive VAC index reflecting myocardial performance.

Methods: In 364 subjects (45.1% women; mean age, 53.8 years; 46.7% hypertensive), we derived echocardiographic indexes of LV structure and function and tonometric measures of central haemodynamics and aortic stiffness. From two-dimensional LV strain curves and simultaneously recorded pressure waveforms, we constructed the pressure-strain loop and calculated ejection work density (EWD), a myocardial performance index, as the area of the pressure-strain loop during LV ejection.

Results: In multivariable-adjusted analysis, EWD increased linearly with age (P < 0.0001). While adjusting for age, anthropometric measures and heart rate, EWD was significantly higher in women and patients with hypertension as compared to men and normotensives, respectively (P < 0.0001 for all). After full adjustment, EWD increased with higher augmentation pressure, central pulse pressure and carotid- femoral pulse wave velocity in both men and women (P≤0.031). Furthermore, EWD correlated independently and directly with left atrial and LV end-diastolic volumes (P≤0.015) as well as peak early diastolic velocities of transmitral flow and mitral annulus movement (P≤0.025).

Conclusion: Higher age, female sex and hypertension were independent determinants of higher EWD. Being associated with indexes reflecting central haemodynamics, arterial stiffness and LV diastolic function, this myocardial performance index might reflect the interaction between LV performance and arterial properties.

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TY  - JOUR
AU  - Nicholas Cauwenberghs
AU  - Jan D’hooge
AU  - Lutgarde Thijs
AU  - Jan A. Staessen
AU  - Tatiana Kuznetsova
PY  - 2017
DA  - 2017/12/06
TI  - P131 DETERMINANTS OF A NEW, NON-INVASIVE INDEX OF VENTRICULAR-ARTERIAL COUPLING AND MYOCARDIAL PERFORMANCE IN A GENERAL POPULATION SAMPLE
JO  - Artery Research
SP  - 82
EP  - 82
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.113
DO  - 10.1016/j.artres.2017.10.113
ID  - Cauwenberghs2017
ER  -