Artery Research

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Volume 20, Issue C, December 2017, Pages 85 - 86

P175 AN ACUTE BOUT OF PROLONGED SITTING IMPAIRS ENDOTHELIAL FUNCTION AND INCREASES PLASMA CONCENTRATIONS OF ENDOTHELIN-1 IN OVERWEIGHT/OBESE ADULTS: IMPLICATIONS FOR GLUCOSE AND INSULIN METABOLISM

Authors
Megan Grace1, 2, Rachel Climie1, Michael Wheeler1, Nina Eikelis1, 3, Joshua Carr1, 2, Francis Dillon1, Neville Owen1, 3, Danny Green4, Bronwyn Kingwell1, David Dunstan1, 5, 2
1Baker Heart and Diabetes Institute, Melbourne, Australia
2Monash University, Melbourne, Australia
3Swinburne University, Melbourne, Australia
4University of Western Australia, Perth, Australia
5Australian Catholic University, Melbourne, Australia
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.123How to use a DOI?
Abstract

Background: Compared to regular active breaks, prolonged uninterrupted sitting amplifies postprandial glucose and insulin in overweight/obese adults with and without type 2 diabetes; and impairs lower limb endothelial function (a predictor of cardiovascular disease) in healthy adults. However, the effects of prolonged sitting on endothelial function in those at heightened risk of cardiometabolic disease have not been investigated.

Methods: Overweight/obese (BMI > 25kg/m2) adults (35–75y) completed two laboratory-based conditions in a random order: (i) 5h prolonged uninterrupted sitting (SIT); and (ii) 5h sitting interrupted with 3min of light-intensity simple resistance activities every 30min (SRA). Femoral artery endothelial function (flow mediated dilation; FMD) and shear rate was assessed at baseline, 1, 2 and 5h. Hourly plasma was collected for glucose, insulin and endothelin-1 measurement. Muscle sympathetic nervous activity (MSNA) was measured at 5h.

2Preliminary results: In the current sample (n = 7), SIT impaired FMD (−2.6±0.9%; p < 0.05) and shear rate iAUC (−39±14%; p < 0.05), compared to SRA. There was an increase in glucose (40±28%; p = 0.18) and insulin (46±25%; p = 0.16) iAUC, and mean endothelin-1 plasma concentration (0.28±0.09 pg/ml; p < 0.05) in SIT, compared to SRA. MSNA (n = 4) was reduced in SIT, compared to SRA (−4±1 bursts/min; p < 0.05). Testing and analysis (n = 20 participants) is expected to be complete by August, 2017.

Conclusions: These findings are consistent with a potential mechanistic link between sitting- induced endothelial dysfunction, vasoconstriction and insulin resistance, via reduced delivery of glucose and insulin to nutritive vascular beds in muscle. Endothelial dysfunction associated with prolonged sitting may be related to reduced shear rate, and impaired MSNA.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
85 - 86
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.123How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Megan Grace
AU  - Rachel Climie
AU  - Michael Wheeler
AU  - Nina Eikelis
AU  - Joshua Carr
AU  - Francis Dillon
AU  - Neville Owen
AU  - Danny Green
AU  - Bronwyn Kingwell
AU  - David Dunstan
PY  - 2017
DA  - 2017/12/06
TI  - P175 AN ACUTE BOUT OF PROLONGED SITTING IMPAIRS ENDOTHELIAL FUNCTION AND INCREASES PLASMA CONCENTRATIONS OF ENDOTHELIN-1 IN OVERWEIGHT/OBESE ADULTS: IMPLICATIONS FOR GLUCOSE AND INSULIN METABOLISM
JO  - Artery Research
SP  - 85
EP  - 86
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.123
DO  - 10.1016/j.artres.2017.10.123
ID  - Grace2017
ER  -