P177 ASSOCIATIONS OF AMBULATORY PULSE PRESSURE COMPONENTS WITH HIPPOCAMPAL VOLUME, WHITE MATTER HYPERINTENSITIES AND BRAIN INFARCTS

DOI

10.1016/j.artres.2017.10.125How to use a DOI?

Abstract

Background: Arterial stiffness is blood pressure (BP) dependent. Using 24-hour ambulatory BP monitoring (24hABPM) pulse pressure (PP) can be split into an ‘elastic’ part (elPP: ‘diastolic stiffness’), and a ‘stiffening’ part (stPP: ‘stiffness change during systole’). We investigated associations of elPP, stPP and PP with brain MRI measures.

Methods: A community-based sample of 542 individuals (59±6y) with 24hABPM and brain MRI, including hippocampal volume (HPCMV), severity of White Matter Hyperintensities (WMH_SVR), and number of brain infarcts (N_INFRCT). ‘High’/’low’ (HI/LO) marked variables status (by medians).

Results: elPP and stPP were weakly correlated (r = 0.15); stPP-to-PP ratio was 0.21±0.08. Adjusted HPCMV calculated at age quartiles for the HI_PP cohort correlated better with values from HI_stPP than from HI_elPP. For HI_PP and HP_stPP HPCMV reduction between age quartiles 1&4 was similar, but 20% larger than for HI_elPP. In hypertensives at highest age quartile HPCMV correlated negatively with stPP (P < 0.05: adjusted for age, sex and diabetes), but not with PP and elPP.

Adjusted WMH_SVR was greater in HI_elPP, HI_PP and HI_elPP comparing diabetics with non-diabetics by 0.38(P = 0.001), 0.29(P = 0.008) and 0.13 (P = 0.25), respectively.

In hypertensives N_INFRCT was greater in past-stroke than no-stroke cohorts in HI&LO elPP, stPP and PP subgroups by 1.96&0.63, 1.48&1.26, and 1.53&1.18 (P < 0.0001 for all).

Conclusion: The association of elastic and stiffening components calculated from ambulatory PP differ for different MRI brain measures and may provide a practical tool for associating arterial properties with brain-related pathological changes. Associations with PP may be mainly explained by its relatively-small stiffening component during systole.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Benjamin Gavish
AU  - Therese Tillin
AU  - Alun D. Hughes
AU  - Nishi Chaturvedi
PY  - 2017
DA  - 2017/12/06
TI  - P177 ASSOCIATIONS OF AMBULATORY PULSE PRESSURE COMPONENTS WITH HIPPOCAMPAL VOLUME, WHITE MATTER HYPERINTENSITIES AND BRAIN INFARCTS
JO  - Artery Research
SP  - 86
EP  - 86
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.125
DO  - 10.1016/j.artres.2017.10.125
ID  - Gavish2017
ER  -