Artery Research

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Volume 20, Issue C, December 2017, Pages 77 - 78

P120 A MODEL-BASED STUDY ON THE EVOLUTION OF BLOOD PRESSURE DURING AGEING

Authors
Stamatia Pagoulatou, Nikolaos Stergiopulos
Laboratory of Hemodynamics and Cardiovascular Technology, EPFL, Switzerland
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.102How to use a DOI?
Abstract

Background: Hypertension being a major risk factor of cardiovascular mortality, there is a pressing need to understand the ageing mechanisms that lead to the continuous increase of pulse pressure and systolic blood pressure over time. Alterations in both forward and backward waves with age have been widely recognized as key features affecting the development of hypertension, with investigators, however, not reaching a consensus on the relative importance of each wave component (1,2).

Objective: The aim of the current investigation was to examine the wave profile over time after developing an age-adapted, mathematical, one-dimensional model of the cardiovascular system.

Methods: Our state-of-the-art 1-D model (3,4) was extended to include turbulence and inertial effects of the flow exiting the left ventricle. Literature data on the age-associated changes in arterial stiffness, peripheral resistance and cardiac contractility were gathered and used as an input for the simulation.

Results: The predicted evolution of pressure and augmentation index with age followed accurately the curves obtained in a number of large-scale clinical studies. Analysis of the relative contribution of the forward and backward wave components showed that the forward wave becomes the major determinant of the increase in central and peripheral SBP and PP with advancing age.

Conclusions: The 1-D model of the ageing tree and heart captures faithfully and with great accuracy the central pressure evolution with ageing. The stiffening of the proximal aorta and the resulting augmentation of the forward pressure wave is the major contributor of the systolic pressure augmentation with age.

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This is an open access article distributed under the CC BY-NC license.

References

1.MF O’Rourke and WW Nichols, Changes in Wave Reflection With Advancing Age in Normal Subjects, Hypertension, Vol. 44, No. 6, 1 Dec 2004, pp. E10-1.
2.GF Mitchell, PR Conlin, ME Dunlap, Y Lacourcière, JMO Arnold, RI Ogilvie, et al., Aortic diameter, wall stiffness, and wave reflection in systolic hypertension, Hypertens Dallas Tex 1979, Vol. 51, No. 1, Jan 2008, pp. 105-11.
3.P Reymond, Y Bohraus, F Perren, F Lazeyras, and N Stergiopulos, Validation of a patient-specific one-dimensional model of the systemic arterial tree, Am J Physiol Heart Circ Physiol, Vol. 301, No. 3, Sep 2011, pp. H1173-1182.
4.P Reymond, F Merenda, F Perren, D Rüfenacht, and N Stergiopulos, Validation of a one-dimensional model of the systemic arterial tree, Am J Physiol – Heart Circ Physiol, Vol. 297, No. 1, 1 Jul 2009, pp. H208-22.
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Journal
Artery Research
Volume-Issue
20 - C
Pages
77 - 78
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.102How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Stamatia Pagoulatou
AU  - Nikolaos Stergiopulos
PY  - 2017
DA  - 2017/12/06
TI  - P120 A MODEL-BASED STUDY ON THE EVOLUTION OF BLOOD PRESSURE DURING AGEING
JO  - Artery Research
SP  - 77
EP  - 78
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.102
DO  - 10.1016/j.artres.2017.10.102
ID  - Pagoulatou2017
ER  -