Artery Research

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Volume 20, Issue C, December 2017, Pages 72 - 72

P64 ARTERIAL STIFFNESS AND PULSE PRESSURE AMPLIFICATION IN ADULTS WITH ISOLATED SYSTOLIC HYPERTENSION

Authors
Rosa Maria Bruno, Francesco Faggioni, Daniele Simone, Stefano Taddei, Ugo Faraguna, Lorenzo Ghiadoni
University of Pisa, Pisa, Italy
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.086How to use a DOI?
Abstract

Background/aim: ISH is usually considered more prevalent in aged individuals and associated to increased large artery stiffness. This study is aimed at identifying determinants of ISH in adult individuals.

Methods: 20 individuals <60 years, referred to the Outpatient Hypertension Unit for high blood pressure (BP) and treatment-naïve, were classified as normotensive (NT), true hypertensives (HT) or isolated systolic hypertensives (ISH) based on office BP. In all individuals the following measurements were obtained: carotid pulse wave velocity (PWV) and aortic BP by applanation tonometry (Sphygmocor CVP, Atcor), 24-h brachial and central BP (Oscar2, SunTech Medical), daily steps by 7-day actigraphy (Fitbit Flex).

Results: the tree groups had similar clinical characteristics, including height and physical activity; only waist circumference was higher in ISH. PWV was normal in ISH and increased in HT. Office brachial and aortic pulse pressure (PP) were greater in ISH than in NT and HT, as well as 24-h brachial and central PP. PP amplification was similar in the three groups either when calculated by tonometry or in 24h.

ISH (n = 7) NT (n = 7) HT (n = 6)
Men 5 5 4
Age (years) 43±15 47±10 41±10
Height (cm) 174±10 171±11 174±11
BMI (kg/mq) 26±2 25±2 24±3
Waist circumference (cm) 93±13* 81±11 81±9
Physical activity (daily steps) 13021±4958 11569±6789 13836±4572
Mean BP (mmHg) 101±9° 90±8 102±13°
Heart rate (bpm) 60±6 61±13 53±10
Office PP (mmHg) 62±9*° 48±7 50±7
Aortic PP (mmHg) 45±8*° 38±4 40±6
24h-brachial PP (mmHg) 55±9* 46±9 51±6
24h-central PP (mmHg) 43±4* 37±4 40±4
24h- PP amplification (mmHg) 12±5 9±2 11±3
Time to reflection (ms) 142±15° 143±13* 161±21*
PWV (m/s) 6.3±1.4° 7.2±2.5° 8.0±2.2*
*:

p < 0.05 vs NT; ° p < 0.05 vs HT.

Conclusions: These preliminary data suggest that adults <60 years, newly diagnosed with ISH, present normal PWV and PP amplification from centre to periphery.

Open Access
This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
72 - 72
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.086How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Rosa Maria Bruno
AU  - Francesco Faggioni
AU  - Daniele Simone
AU  - Stefano Taddei
AU  - Ugo Faraguna
AU  - Lorenzo Ghiadoni
PY  - 2017
DA  - 2017/12/06
TI  - P64 ARTERIAL STIFFNESS AND PULSE PRESSURE AMPLIFICATION IN ADULTS WITH ISOLATED SYSTOLIC HYPERTENSION
JO  - Artery Research
SP  - 72
EP  - 72
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.086
DO  - 10.1016/j.artres.2017.10.086
ID  - Bruno2017
ER  -