Artery Research

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Volume 20, Issue C, December 2017, Pages 75 - 76

P81 DISARRAY AND REMODELING OF THE RADIAL ARTERY IN WOMEN WITH SPONTANEOUS CORONARY ARTERY DISSECTION: THE FUCHSIA STUDY

Authors
Rosa Maria Bruno1, Nicole Di Lascio2, Abtehale Al Hussaini3, Daniela Guarino1, Saverio Vitali1, Piercarlo Rossi1, Davide Caramella1, Bernardo Cortese4, Francesco Faita2, Stefano Taddei1, Lorenzo Ghiadoni1, David Adlam3
1University of Pisa, Pisa, Italy
2Institute of Clinical Physiology – CNR, Pisa, Italy
3University of Leicester, Leicester, UK
4ASST Fatebenefratelli-Sacco, Milano, Italy
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.097How to use a DOI?
Abstract

Background: Spontaneous coronary dissection (SCAD) may represent a manifestation of fibromuscular dysplasia (FMD); thus, preclinical lesions might be found in extracoronary vessels with similar size and wall ultrastructure, such as the radial artery.

Methods: Two 5′-clips from the left radial artery were obtained by Vevo MD (70 MHz probe, FUJIFILM, VisualSonics). Radial wall showed two echogenic interfaces: the 1st (lumen-media) and the 2nd (media-adventitia). Intima-media (IMT), adventitia (AT), and global thickness (IMAT) and wall cross-sectional area (WCSA) Measured.

Vascular wall disarray was assessed calculating the root mean square error (RMSE) between 20 gray-level profiles crossing the two interfaces and the profile obtained averaging them, normalized for the maximum value of the corresponding mean profile (RMSE/mean).

Results: 5 female SCAD patients and 9 healthy controls (C) were enrolled (age 45±9 vs 45±13years, p = 0.95; BMI 21±3 vs 23±kg/mq, p = 0.22; mean BP 77±5 vs 85±10 mmHg, p = 0.053). 2nd interface peak was reduced in the SCAD group (97±29 130±19, p = 0.04), whereas RMSE/mean was increased (1.89±0.68 vs 0.97±0.30, p = 0.02). Similar values were found for the 1st interface. IMT (0.165±0.031 vs 0.125±0.022mm, p = 0.03), but not AT (0.095±0.020 vs 0.081±0.020mm, p = 0.20) and IMAT (0.260±0.049 vs 0.206±0.030mm, p = 0.053), was significantly higher in SCAD.

Radial internal diameter and wall/lumen ratio were similar: conversely WCSA was increased in SCAD (1.69±0.48 vs 1.07±0.37mm2, p = 0.02).

Conclusions: Radial arteries of SCAD patients were characterized by increased wall thickness. Furthermore, the 2nd echogenic layer exhibited loss of echogenicity and inhomogeneity, features similar to FMD patients.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
20 - C
Pages
75 - 76
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.097How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Rosa Maria Bruno
AU  - Nicole Di Lascio
AU  - Abtehale Al Hussaini
AU  - Daniela Guarino
AU  - Saverio Vitali
AU  - Piercarlo Rossi
AU  - Davide Caramella
AU  - Bernardo Cortese
AU  - Francesco Faita
AU  - Stefano Taddei
AU  - Lorenzo Ghiadoni
AU  - David Adlam
PY  - 2017
DA  - 2017/12/06
TI  - P81 DISARRAY AND REMODELING OF THE RADIAL ARTERY IN WOMEN WITH SPONTANEOUS CORONARY ARTERY DISSECTION: THE FUCHSIA STUDY
JO  - Artery Research
SP  - 75
EP  - 76
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.097
DO  - 10.1016/j.artres.2017.10.097
ID  - Bruno2017
ER  -