Artery Research

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Volume 20, Issue C, December 2017, Pages 70 - 70

P58 ARTERIAL STIFFNESS IS ASSOCIATED WITH LOWER PERFORMANCE ON THE COGNITIVE TESTS AT DIFFERENT DOMAINS IN HYPERTENSIVE PATIENTS

Authors
Henrique Muela1, Valeria Costa-Hong1, Michel Machado2, Natalia Moraes2, Claudia Memória2, Monica Yassuda2, Edson Shu2, Ayrton Massaro2, Ricardo Nitrini2, Alfredo Mansur1, Luiz Bortolotto3
1Hypertension Unity, Heart Instiute (InCor), Hospital das Clinicas da FMUSP, Sao Paolo, Brazil
2Neurology Department, Hospital das Clinicas da FMUSP, Sao Paolo, Brazil
3Hypertension Unity, Heart Institute (InCor), Hospital das Clinicas da FMUSP, Sao Paolo, Brazil
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.080How to use a DOI?
Abstract

Background: Cognitive impairment and elevated arterial stiffness are described in arterial hypertension (AH), but its correlations are not well studied.

Objectives: To study the cognitive function at different domains and arterial properties in patients with AH stage 1 to 3 compared to normotensives and to evaluate the correlations between these variables.

Methods: We evaluated 71 normotensives (52±14 yrs, 47% male, 65% white) and 150 patients with stage 1–3 AH (52±12 yrs, 45% male, 70% white) under treatment. The global cognitive function was assessed by Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA).A validated battery of neuropsychological tests (NPE) assessed the main cognitive areas: memory, language, visuospatial ability, executive function, attention. Pulse wave velocity (PWV) was measured by Complior® device. Carotid properties were assessed by radiofrequency ultrasound (WTS®). Central arterial pressure and augmentation index (AIx) were obtained using applanation tonometry (Sphygmocor®).

Results: Mean BP of the normotensive group (122.1±8/76.7±7 mmHg) was significantly lower than hypertensive patients (135.2±13/83.3±10 and 149.9±29/91.5±16 mmHg). Severe HTN group had worse performance in cognitive evaluation either by MMSE (26.8±2.1 vs 27.4±2.1 vs. 28.0±2.0, p = 0.004) or MoCA test (23.4±3.7 vs. 24.9±2.8 vs. 25.5±3.2, p < 0.001). On the neuropsychological tests hypertensive patients had worse performance mainly in visuoperceptual and visuospatial capacities and executive function. On the multivariate regression analysis, the following independent associations were observed: Aix–language, executive function, visuospatial and attention; cSBP–MoCA; IMT–memory and attention; PWV–memory, executive function, visuospatial and attention. Higher PWV group had more cognitive dysfunction.

Conclusions: Cognitive impairment at different domains was more frequent in patients with different stages of AH. Arterial functional and structural properties were diversely associated with cognitive performance at different domains.

Open Access
This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
70 - 70
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.080How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Henrique Muela
AU  - Valeria Costa-Hong
AU  - Michel Machado
AU  - Natalia Moraes
AU  - Claudia Memória
AU  - Monica Yassuda
AU  - Edson Shu
AU  - Ayrton Massaro
AU  - Ricardo Nitrini
AU  - Alfredo Mansur
AU  - Luiz Bortolotto
PY  - 2017
DA  - 2017/12/06
TI  - P58 ARTERIAL STIFFNESS IS ASSOCIATED WITH LOWER PERFORMANCE ON THE COGNITIVE TESTS AT DIFFERENT DOMAINS IN HYPERTENSIVE PATIENTS
JO  - Artery Research
SP  - 70
EP  - 70
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.080
DO  - 10.1016/j.artres.2017.10.080
ID  - Muela2017
ER  -