Artery Research

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Volume 20, Issue C, December 2017, Pages 73 - 73

P74 WALL SHEAR RATE AND BRACHIAL ARTERY FLOW-MEDIATED DILATORY RESPONSE BETWEEN HEALTHY YOUNG AND OLDER POPULATIONS USING MULTI-GATE SPECTRAL DOPPLER ULTRASOUND

Authors
Kunihiko Aizawa1, Sara Sbragi2, Alessandro Ramalli3, Piero Tortoli3, Francesco Casanova1, Carmela Morizzo2, Clare Thorn1, Angela Shore1, Phillip Gates1, Carlo Palombo2
1Diabetes and Vascular Medicine Research Centre, NIHR Exeter Clinical Research Facility, University of Exeter Medical School, UK
2Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa, Italy
3Department of Information Engineering, University of Florence, Italy
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.090How to use a DOI?
Abstract

Background: Ageing is associated with an impaired brachial artery flow-mediated dilatation (FMD) response and a reduced wall shear rate (WSR) stimulus may contribute to this response. However, a detailed analysis of the WSR-FMD response is lacking due to inherent difficulties of WSR estimation near the arterial wall by conventional ultrasound. We have overcome this limitation by using an integrated multi-gate Doppler FMD evaluation system, and in this study, we compared the WSR-FMD relationship between a healthy young and older population.

Methods: Data from 33 young (YNG: 27.5±4.9yrs) and 33 older (OLD: 64.9±3.6yrs) individuals were analysed. FMD was assessed using Ultrasound Advanced Open Platform (ULA-OP). Acquired raw data were post-processed using custom-designed software to obtain WSR and diameter parameters.

Results: Peak WSR [WSRpk: 635(585–685) vs 424(374–473) s−1] and absolute WSR increase [WSRΔ: 548(504–592) vs 356(313–400) s−1] were greater in YNG than OLD (both p < 0.05). WSR area under the curve until its return to baseline value (WSRauc) was also greater in YNG than OLD [18632(16395–20868) vs 13049(10812–15285) au, p < 0.05]. WSRpk, WSRΔ and WSRauc were associated with both absolute and percentage diameter increases in YNG (all p < 0.05). However, none of the WSR parameters in OLD were associated with absolute or percentage diameter increases.

Conclusions: These results demonstrate 1) a reduced WSR stimulus during reactive hyperaemia in OLD compared with YNG, and 2) the absence of an association between WSR parameters and FMD response in OLD. These observations suggest that in older adults, diminished WSR together with WSR-independent factors are important determinants of the FMD response.

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<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
20 - C
Pages
73 - 73
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.090How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Kunihiko Aizawa
AU  - Sara Sbragi
AU  - Alessandro Ramalli
AU  - Piero Tortoli
AU  - Francesco Casanova
AU  - Carmela Morizzo
AU  - Clare Thorn
AU  - Angela Shore
AU  - Phillip Gates
AU  - Carlo Palombo
PY  - 2017
DA  - 2017/12/06
TI  - P74 WALL SHEAR RATE AND BRACHIAL ARTERY FLOW-MEDIATED DILATORY RESPONSE BETWEEN HEALTHY YOUNG AND OLDER POPULATIONS USING MULTI-GATE SPECTRAL DOPPLER ULTRASOUND
JO  - Artery Research
SP  - 73
EP  - 73
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.090
DO  - 10.1016/j.artres.2017.10.090
ID  - Aizawa2017
ER  -