Artery Research

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Volume 20, Issue C, December 2017, Pages 69 - 69

P55 TARGET ORGAN DAMAGE AND BLOOD PRESSURE VARIABILITY IN HYPERTENSION

Authors
Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Athanasios Angelis, Nikolaos Loakeimidis, Panagiotis Xaplanteris, Christos Georgakopoulos, Evangelia Sigala, Losif Koutagiar, Angeliki Rigatou, Dimitrios Tousoulis
Peripheral Vessels Unit, First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.077How to use a DOI?
Abstract

Purpose/Background/Objectives: Hypertension is associated with several markers of subclinical target organ damage (TOD). Short-term blood pressure variability (SBPV) is a prognostic factor for cardiovascular events in hypertensives. We hypothesised that there is a relationship between SBPV and TOD in never-treated hypertensives.

Methods: We enrolled 943 consecutive essential hypertensives (mean age 53±12 years, 497 males). Markers of subclinical TOD [left ventricular mass index (LVMI), pulse wave velocity (PWV), total arterial compliance (TAC), aortic augmentation index (AIx@75), ankle-brachial index (ABI) and estimated glomerular filtration rate (eGFR)] and 24-h ambulatory blood pressure were evaluated in all patients. SBPV was calculated as follows: 1) SD of 24-hour, daytime, or nighttime SBP and 2) weighted SD of 24-hour SBP.

Results: In multivariable regression analysis, all four variables of SBPV exhibited significant association with LVMI (p = 0.014, p = 0.002, p = 0.002 and p < 0.001, respectively), PWV (p = 0.021, p = 0.015, p = 0.055 and p = 0.006, respectively) and TAC (p = 0.048, p = 0.020, p = 0.036 and p = 0.006, respectively). In multivariable analysis, ABI and eGFR were not associated with indices of SBPV. We assessed TOD based on 2013 European Guidelines for Hypertension [left ventricular hypertrophy (LVMI > 115 g/m2 in men and >95 g/m2 in women), increased PWV (PWV > 10m/s), increased AIx@75 (AIx@75 > 28%), decreased ABI (ABI < 0.9) and decreased renal function (eGFR < 60ml/min)]. In multivariable logistic regression analysis, SBPV indices were not associated with markers of TOD (P > 0.05).

Conclusions: Our findings support a complex relationship between SBPV and TOD in hypertension. Specifically, SBPV is more closely related to markers of ventricular and vascular compliance than other markers of TOD in hypertension.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
69 - 69
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.077How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Dimitrios Terentes-Printzios
AU  - Charalambos Vlachopoulos
AU  - Athanasios Angelis
AU  - Nikolaos Loakeimidis
AU  - Panagiotis Xaplanteris
AU  - Christos Georgakopoulos
AU  - Evangelia Sigala
AU  - Losif Koutagiar
AU  - Angeliki Rigatou
AU  - Dimitrios Tousoulis
PY  - 2017
DA  - 2017/12/06
TI  - P55 TARGET ORGAN DAMAGE AND BLOOD PRESSURE VARIABILITY IN HYPERTENSION
JO  - Artery Research
SP  - 69
EP  - 69
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.077
DO  - 10.1016/j.artres.2017.10.077
ID  - Terentes-Printzios2017
ER  -