5.3 HIGH FIT OLDER ADULTS MAINTAIN A SIMILAR ENDOTHELIAL RESPONSE TO ACUTE INFLAMMATION AS YOUNGER ADULTS

DOI

10.1016/j.artres.2017.10.049How to use a DOI?

Abstract

Inflammation is associated with an increased risk of cardiovascular events and reduced endothelial function. Higher cardiorespiratory fitness is associated with lower risk of cardiovascular events and improved vascular function. Whether fitness plays a role during acute inflammation is unknown.

Purpose: Evaluate the role of fitness in the endothelial response to acute inflammation in younger (YA) and older (OA) adults.

Methods: Acute inflammation was induced using influenza vaccine in 23 YA (12 male, 26 ± 4 yrs, 24.0 ± 3.5 kg/m²) and 60 OA (20 male, 65 ± 5 yrs, 27.8 ± 5.0 kg/m²). Blood pressure, flow-mediated dilation (FMD) and inflammatory markers were measured before and 24-hours post-vaccination. VO₂peak was measured via a treadmill test. A VO₂peak greater than age- and sex-associated 50th percentile according to the American College of Sports Medicine was defined as Fit.

Results: Fit OA reduced FMD more than low fit OA (p = 0.02) 24 h post-vaccination. High and low fit YA similarly decreased FMD at 24 h (p = 0.66). YA and high fit OA had a similar reduction (relative %) in FMD (pz0.05). Regression analyses indicated no association between VO₂peak and change in FMD (β = −0.01, p = 0.98) in YA, but a significant association existed in OA (β = −0.36, p = 0.04) after adjusting for age, sex, BMI and baseline FMD.

	YA-high fit	YA-low fit	OA-high fit	OA-low fit
n	14	9	16	43
VO2Max, ml/kg/min	48.4 (5.6)*	35.6 (4.9)	32.3 (4.2)*	21.9 (4.3)
Baseline SBP	113 (13)	115 (13)	125 (14)	125 (14)
Baseline PP	47 (8)	47 (11)	54 (10)	53 (11)
Baseline FMD, %	12.4 (2.7)	11.6 (5.5)	7.5 (3.9)*	5.4 (2.5)
Baseline CRP, mg/1	1.1 (0.7)	0.6 (0.6)	2.4 (3.3)	2.5 (2.2)
Baseline IL-6, pg/ml	1.0 (0.7)	0.8 (0.5)	1.7 (1.4)	1.6 (1.1)
Change SBP, mmHg	−3 (6)	2 (8)	−2 (9)	−2 (11)
Change PP, mmHg	2 (6)	5 (7)	0 (7)	0 (8)
Change FMD, %	−3.2 (4.1)	−2.3 (5.5)	−3.7 (3.8)*	−0.2 (3.5)
Change CRP, mg/l	1.0 (1.5)	0.9 (0.8)	1.1 (2.2)	0.9 (1.4)
Change IL, pg/ml	1.0 (1.5)	1.6 (2.3)	0.8 (2.6)	0.4 (1.0)

FMD: flow mediated dilation, CRP: C-reactive protein, IL-6: interleukin-6, SBP: systolic blood pressure, PP: pulse pressure

*

P < 00.5 vs. low-fit of same age category

Conclusion: In OA, higher fitness is associated with a greater decrease in endothelial function during acute inflammation; high fit OA had a similar endothelial response compared to YA. This suggests intact reactivity of the vasculature to inflammatory stress in high fit OA, which may indicate a healthier vessel versus low fit OA.

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TY  - JOUR
AU  - Elizabeth Schroeder
AU  - Abbi Lane-Cordova
AU  - Sushant Ranadive
AU  - Tracy Baynard
AU  - Bo Fernhall
PY  - 2017
DA  - 2017/12/06
TI  - 5.3 HIGH FIT OLDER ADULTS MAINTAIN A SIMILAR ENDOTHELIAL RESPONSE TO ACUTE INFLAMMATION AS YOUNGER ADULTS
JO  - Artery Research
SP  - 59
EP  - 59
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.049
DO  - 10.1016/j.artres.2017.10.049
ID  - Schroeder2017
ER  -