5.4 EFFECT OF ACUTE RESISTANCE EXERCISE ON ARTERIAL HEMODYNAMICS AND CEREBRAL BLOOD FLOW DYNAMICS: DOES SEX MATTER?

Alexander Rosenberg; Tommy Wee; Elizabeth Schroeder; Kanokwan Bunsawat; Georgios Grigoriadis; Garett Griffith; Bo Fernhall; Tracy Baynard

doi:10.1016/j.artres.2017.10.050

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Volume 20, Issue C, December 2017, Pages 59 - 60

5.4 EFFECT OF ACUTE RESISTANCE EXERCISE ON ARTERIAL HEMODYNAMICS AND CEREBRAL BLOOD FLOW DYNAMICS: DOES SEX MATTER?

Authors

Alexander Rosenberg, Tommy Wee, Elizabeth Schroeder, Kanokwan Bunsawat, Georgios Grigoriadis, Garett Griffith, Bo Fernhall, Tracy Baynard

Integrative Physiology Laboratory, University of Illinois at Chicago, Chicago, IL, USA

Available Online 6 December 2017.

DOI

10.1016/j.artres.2017.10.050 How to use a DOI?

Abstract

High-intensity resistance exercise (RE) acutely increases arterial stiffness and blood pressure (BP), coupled with reduced cerebral blood flow velocity (CBFv) and greater flow pulsatility in the cerebral circulation, which may be detrimental to cerebral microvasculature. Because females have different CV control mechanisms, it is important to assess potential sex differences in cerebrovascular responses to acute RE.

Purpose: To examine the effect of sex on hemodynamics and cerebral vasculature following acute RE.

Methods: Men (n = 18, 27 yrs, BMI = 24.2) and women (n = 14, 25 yrs, BMI = 23.8) performed RE (3 × 10, isokinetic knee flexion/extension). Measurements were obtained at baseline and post-exercise (1, 5, 30-minute). Beat-to-beat heart rate (HR), brachial BP, cardiac output (CO), stroke volume and end-tidal CO₂ were collected. CBFv was measured by transcranial Doppler, carotid BP by applanation tonometry and central pulse wave velocity (PWV) by an automated ambulatory BP monitor.

Results: Table 1. CBFv pulsatility increased following RE at 1-minute post (p < 0.05) in men and was elevated above baseline 5-minute post-exercise (p < 0.05) in both groups (Figure 1). Mean CBFv increased 1-min post-exercise and decreased below baseline 5-minute post-exercise (p < 0.05) in both sexes. PWV increased 1-minute post-exercise (p < 0.05) in both groups.

Variables		Baseline	1-minute	5-minute	30-minute
Heart Rate(bpm)^*†	Men	63 ± 9	82 ± 9	71 ± 10	70 ± 8
Heart Rate(bpm)^*†	Women	70 ± 7	93 ± 13	79 ± 10	76 ± 9
CO (L/min) ^*	Men	4.9 ± 0.7	7.9 ± 1.3	6.1 ± 1.3	5.2 ± 0.9
CO (L/min) ^*	Women	5.4 ± 1.0	8.2 ± 1.4	6.3 ± 1.0	5.7 ± 0.8
SV (ml/min)^*‡	Men	77 ± 16^ab	95 ± 17^bc	85 ± 17^c	72 ± 13
SV (ml/min)^*‡	Women	80 ± 17^a	91 ± 20^bc	81 ± 14	76 ± 16
bSBP (mmHg)^*	Men	124 ± 10	140 ± 12	127 ± 10	127 ± 9
bSBP (mmHg)^*	Women	124 ± 9	136 ± 15	122 ± 13	123 ± 9
bDBP (mmHg)^*	Men	72 ± 8	74 ± 7	72 ± 7	76 ± 6
bDBP (mmHg)^*	Women	73 ± 5	76 ± 9	71 ± 7	73 ± 5
bMAP (mmHg)^*	Men	92 ± 8	100 ± 8	93 ± 8	96 ± 7
bMAP (mmHg)^*	Women	95 ± 6	101 ± 11	93 ± 8	95 ± 6
cSBP (mmHg)^*	Men	120 ± 12	129 ± 18	125 ± 13	126 ± 10
cSBP (mmHg)^*	Women	1 22 ± 12	124 ± 13	119 ± 18	123 ± 8
cDBP (mmHg)^*	Men	75 ± 7	74 ± 7	75 ± 7	79 ± 6
cDBP (mmHg)^*	Women	74 ± 6	73 ± 6	75 ± 7	74 ± 5
cMAP (mniHg)^*	Men	93 ± 8	94 ± 8	94 ± 7	97 ± 7
cMAP (mniHg)^*	Women	94 ± 6	93 ± 8	95 ± 9	96 ± 5
PWV (m/s)^*	Men	5.2 ± 0.5	5.6 ± 0.5	5.4 ± 0.5	5.2 ± 0.3
PWV (m/s)^*	Women	5.0 ± 0.4	5.3 ± 0.5	5.1 ± 0.3	5.0 ± 0.3
CBFv Mean (cm/s)^*†	Men	55.8 ± 7.6	63.9 ± 9.6	51.4 ± 6.9	53.7 ± 7.9
CBFv Mean (cm/s)^*†	Women	69.8 ± 14.4	81.0 ± 23.1	63.7 ± 12.9	65.8 ± 12.0
CBFv Pulsatility Index^*†‡	Men	0.91 ± 0.12^ab	1.10 ± 0.16^*	1.13 ± 0.17^c	0.89 ± 0.13
CBFv Pulsatility Index^*†‡	Women	0.81 ± 0.09^b	0.90 ± 0.18	0.95 ± 0.13^c	0.81 ± 0.11
End-Tidal CO₂ (%)^*	Men	4.86 ± 0.48	5.72 ± 0.66	4.64 ± 0.51	4.51 ± 0.58
End-Tidal CO₂ (%)^*	Women	4.41 ± 0.60	5.44 ± 0.65	4.26 ± 0.39	4.24 ± 0.50

Table 1

All Data are mean ± SD; ^*Exercise effect, p < 0.05. †Group effect. p < 0.05. ‡Interaction effect. p < 0.05. a Significantly different from 1-minute, b Significantly different from 5-minute. c Significantly different from 30-minute. p < 0.05). Brachial systolic BP (bSBP), brachial diastolic BP (bDBP), brachial mean BP (bMAP), Carotid systolic BP (cSBP),carotid diastolic BP (cDBP), cardiac output (CO), stroke volume (SV) and central pulse wave velocity (PWV), cerebral blood flow velocity (CBFv).

Conclusion: Men increased CBFv pulsatility at 1-minute post-RE compared to women, demonstrating a sex difference in cerebral vascular reactivity. RE increased central arterial stiffness, mean CBFv, HR, and BP similarly for both sexes. CO was also elevated at 5-minute, but CBFv dropped below baseline and pulsatility continued to rise above baseline. This temporary disruption in cerebral autoregulation may impact brain health in both sexes.

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Journal: Artery Research
Volume-Issue: 20 - C
Pages: 59 - 60
Publication Date: 2017/12/06
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2017.10.050 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Alexander Rosenberg
AU  - Tommy Wee
AU  - Elizabeth Schroeder
AU  - Kanokwan Bunsawat
AU  - Georgios Grigoriadis
AU  - Garett Griffith
AU  - Bo Fernhall
AU  - Tracy Baynard
PY  - 2017
DA  - 2017/12/06
TI  - 5.4 EFFECT OF ACUTE RESISTANCE EXERCISE ON ARTERIAL HEMODYNAMICS AND CEREBRAL BLOOD FLOW DYNAMICS: DOES SEX MATTER?
JO  - Artery Research
SP  - 59
EP  - 60
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.050
DO  - 10.1016/j.artres.2017.10.050
ID  - Rosenberg2017
ER  -

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