Artery Research

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Volume 20, Issue C, December 2017, Pages 50 - 50

2.3 BIOMECHANICAL AND STRUCTURAL QUANTIFICATION OF VASCULAR DAMAGE: A UNIQUE INVESTIGATION OF STENT IMPLANTATION

Authors
Markus A. Geith1, 2, 3, Gerhard Sommer1, Thomas Schratzenstaller2, 3, Gerhard A. Holzapfel1
1Institute of Biomechanics, Graz University of Technology, Austria
2Laboratory for Medical Devices, OTH Regensburg, Germany
3Regensburg Center of Biomedical Engineering, OTH & University Regensburg, Germany
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.025How to use a DOI?
Abstract

The most challenging complication after coronary stent implantation is in-stent restenosis [1], which is mainly caused by mechanically induced injuries due to overloading. From a biomechanical point of view, the processes occurring inside the arterial tissues during stent implantation (SI) is rather unknown.

This study shows a novel approach to quantify vascular damage due to SI a multi-scale examination of coronary arteries with generated injuries using a unique experimental in vitro setup.

The setup consists of a biaxial tensile testing stage to apply physiological loads on rectangular specimens of coronary arteries and a triple-axis-unit, which allows the indentation of stent struts into arterial tissues under a specified pressure (Fig. A). In addition, the multi-scale investigation of the mechanical and structural responses of the resulting lesion, following the protocol of Sommer et al. [2], is carried out by calculating Cauchy stresses and analyzing healthy and injured specimens with second harmonic generation (Fig. B) and electron microscopy.

The results indicate that the usually wavy collagen fibers straightened, compress and align around the lesion (Fig. B). In addition, the evaluation of the material characteristics reveals a significant softening of injured tissues.

Fig. A:

Design of the experimental setup, showing a biaxial tensile testing stage (white parts) and the triple-axis-unit for indentation tests (yellow parts).

Fig. B:

Sectional view through the tissue perpendicular to the lesion. The SHG images show collagen fibers of specimens from a 6-months-old porcine descending aorta responding under different pressures (1 and 4 MPa).

Open Access
This is an open access article distributed under the CC BY-NC license.

References

1.KH Bønaa, J Mannsverk, R Wiseth, L Aaberge, Y Myreng, O Nygard, et al., Drug-eluting or bare-metal stents for coronary artery disease, N Engl J Med, Vol. 375, 2016, pp. 1242-52.
2.G Sommer, AJ Schriefl, M Andra, M Sacherer, C Viertler, H Wolinski, et al., Biomechanical properties and microstructure of human ventricular myocardium, Acta Biomater, Vol. 24, 2015, pp. 172-92.
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Journal
Artery Research
Volume-Issue
20 - C
Pages
50 - 50
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.025How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Markus A. Geith
AU  - Gerhard Sommer
AU  - Thomas Schratzenstaller
AU  - Gerhard A. Holzapfel
PY  - 2017
DA  - 2017/12/06
TI  - 2.3 BIOMECHANICAL AND STRUCTURAL QUANTIFICATION OF VASCULAR DAMAGE: A UNIQUE INVESTIGATION OF STENT IMPLANTATION
JO  - Artery Research
SP  - 50
EP  - 50
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.025
DO  - 10.1016/j.artres.2017.10.025
ID  - Geith2017
ER  -