Artery Research

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Volume 20, Issue C, December 2017, Pages 47 - 48

1.3 DETERMINANTS OF CENTRAL AND PERIPHERAL PULSE PRESSURE IN A POPULATION OF HEALTHY ADOLESCENTS. THE MACISTE STUDY

Authors
Pucci Giacomo1, 2, Battista Francesca1, 2, D’Abbondanza Marco1, 2, Papi Francesco1, 2, Schillaci Giuseppe1, 2
1Department of Medicine, University of Perugia, Perugia, Italy
2Unit of Internal Medicine, Terni University Hospital, Terni, Italy
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.017How to use a DOI?
Abstract

We aimed at evaluating the anthropometric and hemodynamic factors associated with central pulse pressure (cPP), peripheral pulse pressure (pPP) and central-to-peripheral PP amplification (PPamp) in healthy adolescents.

We studied 459 subjects (boys 57%, 16.8 ± 1.5 y) attending the Liceo Donatelli High School in Terni, Italy. cPP was estimated from radial applanation tonometry (SphygmoCor GTF) calibrated to brachial MAP/DBP. Indexed left ventricular mass (iLVM = LVM/BSA) and stroke index (SI = stroke volume/BSA) were derived from 2D-echocardiography (Teicholz’s formula, Devereux correction). Carotid-femoral (cf-PWV) and carotid-radial (cr-PWV) pulse wave velocities were measured by SphygmoCor. cPP, pPP and PPamp were introduced as dependent variables in three separate stepwise multivariate regression models. Age, male sex, BSA, heart rate (HR), MAP, stroke index (SI: stroke volume/BSA) and cf-PWV were included in each model as independent factors.

Average cPP was 36 ± 7 mmHg, PPamp 1.57 ± 0.13. cPP was positively associated with male sex, BSA, MAP, SI, and negatively with HR (47% of cPP variance explained). pPP was positively associated with male sex, BSA and SI (44% of pPP variance explained). PPamp was positively associated with age, HR and cf-PWV (17% of PPamp variance explained). Results did not change when BMI and height replaced BSA, iLVM replaced SI, and cr-PWV or PWV ratio (cfPWV/crPWV) replaced cf-PWV.

Anthropometric and hemodynamic factors differently impact on cPP, pPP and PPamp. HR and MAP are related to cPP, but not to pPP. HR, cf-PWV and age are all positively related to PPamp. These results could help in better elucidate the clinical relevance of some BP patterns frequently observed in adolescence.

cPP pPP PPamp
Standardized β Standardized β Standardized β
Male sex 0.33 0.40 –
BSA, m2 0.28 0.32 –
Heart rate, bpm −0.21 – 0.32
Mean arterial pressure, mmHg 0.11 – –
Stroke index, ml/m2 0.09 0.09 –
Carotid-femoral PWV, m/s – – 0.11
Age, years – – 0.10
Table

independent determinants of cPP, pPP and PPamp. All the showed coefficients had p < 0.05.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
47 - 48
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.017How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Pucci Giacomo
AU  - Battista Francesca
AU  - D’Abbondanza Marco
AU  - Papi Francesco
AU  - Schillaci Giuseppe
PY  - 2017
DA  - 2017/12/06
TI  - 1.3 DETERMINANTS OF CENTRAL AND PERIPHERAL PULSE PRESSURE IN A POPULATION OF HEALTHY ADOLESCENTS. THE MACISTE STUDY
JO  - Artery Research
SP  - 47
EP  - 48
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.017
DO  - 10.1016/j.artres.2017.10.017
ID  - Giacomo2017
ER  -