Artery Research

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Volume 20, Issue C, December 2017, Pages 48 - 48

1.5 DESPHOSPHO-UNCARBOXYLATED MATRIX GLA PROTEIN IS A NOVEL CIRCULATING BIOMARKER PREDICTING DETERIORATION OF RENAL FUNCTION IN THE GENERAL POPULATION

Authors
Fangfei Wei1, Sander Trenson1, Lutgarde Thijs1, Qi-Fang Huang1, Zhen-Yu Zhang1, Wen-Yi Yang1, Paula Moliterno2, Karel Allegaert3, José Boggia4, Stefan Janssens1, Peter Verhamme1, Cees Vermeer5, Jan Staessen1
1Department of Cardiovascular Sciences, University of Leuven, Belgium
2Escuela de Nutrición, Universidad de la República, Uruguay
3Department of Development and Regeneration, University of Leuven, Belgium
4Centro de Nefrología and Departamento de Fisiopatología, Hospital de Clínicas, Universidad de la República, Uruguay
5R&D Group VitaK, Maastricht University, Netherlands
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.019How to use a DOI?
Abstract

Background: Recent studies showing an inverse association between estimated glomerular filtration rate (eGFR), a microvascular trait, and inactive desphospho-uncarboxylated matrix Gla protein (dp-ucMGP) support the hypothesis that after vitamin K dependent activation MGP is renoprotective, but were limited by their cross-sectional design.

Methods: In 1009 randomly recruited Flemish (50.6% women), we assessed the association between eGFR and plasma dp-ucMGP, using multivariable-adjusted analyses.

Results: From baseline to follow-up 8.9 years later (median), dp-ucMGP increased by 3.7%, whereas eGFR decreased by 4.05 ml/min/1.73 m2 (P < 0.001). In 938 participants with baseline eGFR ≥ 60 ml/min/1.73 m2, incidence of eGFR < 60 ml/min/1.73 m2 at follow-up was 8.0% vs. 4.1% in the top vs. the bottom halve of baseline dp-ucMGP. For each doubling of baseline dp-ucMGP, eGFR at follow-up decreased by 1.36 ml/min/1.73 m2 [95% confidence interval (CI) 0.55–2.17 ml/min/1.73 m2; P = 0.001]. The hazard ratio expressing the risk of progression to eGFR < 60 ml/min/1.73 m2 was 1.67 (95% CI 1.16–2.41; P = 0.006). The hazard ratio relating the presence of microalbuminuria at follow-up to baseline dp-ucMGP was 1.96 (95% CI 1.22–3.12; P = 0.005).

Conclusions: In conclusion, circulating inactive dp-ucMGP, a biomarker of poor vitamin K status, predicts renal dysfunction. Possible underlying mechanisms include protection by activated MGP against calcification and inhibition of bone morphogenetic protein signaling pathway.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
20 - C
Pages
48 - 48
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.019How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Fangfei Wei
AU  - Sander Trenson
AU  - Lutgarde Thijs
AU  - Qi-Fang Huang
AU  - Zhen-Yu Zhang
AU  - Wen-Yi Yang
AU  - Paula Moliterno
AU  - Karel Allegaert
AU  - José Boggia
AU  - Stefan Janssens
AU  - Peter Verhamme
AU  - Cees Vermeer
AU  - Jan Staessen
PY  - 2017
DA  - 2017/12/06
TI  - 1.5 DESPHOSPHO-UNCARBOXYLATED MATRIX GLA PROTEIN IS A NOVEL CIRCULATING BIOMARKER PREDICTING DETERIORATION OF RENAL FUNCTION IN THE GENERAL POPULATION
JO  - Artery Research
SP  - 48
EP  - 48
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.019
DO  - 10.1016/j.artres.2017.10.019
ID  - Wei2017
ER  -