Artery Research

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Volume 24, Issue C, December 2018, Pages 128 - 128

P165 EVALUATING CAROTID FEMORAL PULSE WAVE VELOCITY MEASURED BY CUFF-BASED APPROACH AGAINST THE TONOMETRY-BASED REFERENCE STANDARD IN A PAEDIATRIC POPULATION

Authors
Tommy Cai1, 2, Alice Meroni1, Hasthi Dissanayake1, Melinda Phang1, Alberto Avolio3, David Celermajer1, 4, Mark Butlin3, Michael Skilton1, Ahmad Qasem3
1School of Medicine, University of Sydney, Sydney, Australia
2Royal Prince Alfred Hospital, Sydney, Australia
3The Australian School of Advanced Medicine, Macquarie university, Sydney, Australia
4ZDepartment of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.218How to use a DOI?
Abstract

Background: Carotid femoral pulse wave velocity (cfPWV) is directly associated with arterial stiffness in major elastic arteries and predicts future cardiovascular events (1). Little is known of cfPWV as a marker of vascular health in children. Semi-automated cuff-based devices for assessing cfPWV are increasingly popular, although these utilize an algorithm developed and validated in adults (2). Physiological differences between adults and children may thus reduce the accuracy of cuff-based.

Methods: We sought to determine the accuracy of a cuff-based cfPWV device in healthy children and determine whether an age-appropriate algorithm increases accuracy. Methods we prospectively recruited 29 healthy children (mean age = 11.5 ± 5.2 years old). cfPWV was measured using a tonometer on the carotid artery and an inflated cuff on the thigh (Sphygmocor XCEL; AtCor Medical, Australia), and using a tonometer on both the carotid artery and femoral artery (SphygmoCor CvMS; AtCor Medical, Australia) as a reference method. We assessed the accuracy of the cuff-based device with its standard algorithm that was developed in adults, and an adjusted algorithm corrected for physiological differences in leg (femoral to thigh cuff) PWV between adult and children (3).

Results: Cuff-based device estimates of cfPWV in children had excellent agreement to the reference standard (r = 0.85; Δ = −0.26 ms−1 [SD 0.44]). The adjusted algorithm improved the accuracy of the cuff-based method (r = 0.84; Δ=0.02 ms−1 [SD 0.44]) (Figure 1).

Conclusions: Although the cuff-based semi-automatic approach estimates cfPWV with excellent agreement to the reference standard, adjusting the algorithm for known differences in leg PWV improves the accuracy of cuff-based measurement in children.

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This is an open access article distributed under the CC BY-NC license.

References

1.S Laurent, J Cockcroft, L Van Bortel, P Boutouyrie, C Giannattasio, D Hayoz, et al., Expert consensus document on arterial stiffness: methodological issues and clinical applications, Eur Heart J., Vol. 27, No. 21, 2006, pp. 2588-605.
2.M Butlin, A Qasem, F Battista, E Bozec, CM McEniery, E Millet-Amaury, et al., Carotid-femoral pulse wave velocity assessment using novel cuff-based techniques: comparison with tonometric measurement, J Hypertens, Vol. 31, No. 11, 2013, pp. 2237-43.
3.AP Avolio, SG Chen, RP Wang, CL Zhang, MF Li, and MF O’Rourke, Effects of aging on changing arterial compliance and left ventricular load in a northern Chinese urban community, Circulation, Vol. 68, No. 1, 1983, pp. 50-8.
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Journal
Artery Research
Volume-Issue
24 - C
Pages
128 - 128
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.218How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Tommy Cai
AU  - Alice Meroni
AU  - Hasthi Dissanayake
AU  - Melinda Phang
AU  - Alberto Avolio
AU  - David Celermajer
AU  - Mark Butlin
AU  - Michael Skilton
AU  - Ahmad Qasem
PY  - 2018
DA  - 2018/12/04
TI  - P165 EVALUATING CAROTID FEMORAL PULSE WAVE VELOCITY MEASURED BY CUFF-BASED APPROACH AGAINST THE TONOMETRY-BASED REFERENCE STANDARD IN A PAEDIATRIC POPULATION
JO  - Artery Research
SP  - 128
EP  - 128
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.218
DO  - 10.1016/j.artres.2018.10.218
ID  - Cai2018
ER  -