Artery Research

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Volume 24, Issue C, December 2018, Pages 124 - 124

P152 THE EFFECT OF SURGICAL AORTIC VALVE REPLACEMENT ON AORTIC STIFFNESS AND THE PROGNOSTIC ROLE OF AORTIC STIFFNESS ON SURGICAL SUCCESS

Authors
Evangelia Sigala1, Dimitrios Terentes-Printzios1, Charalambos Vlachopoulos1, Konstantinos Triantafillou2, Nikolaos Koumallos2, Andreas Katsaros2, Vasilios Lozos2, Ilias Kouerinis2, Nikolaos Giakis2, Michael Demosthenous1, Konstantinos Filis3, Dimitrios Tousoulis1
1Hippokration Hospital, University of Athens, 1st department of Cardiology, Athens, Greece
2Hippokration General Hospital, Department of Cardiac Surgery, Athens, Greece
3Hippokration General Hospital, First Department of Propaedeutic Surgery, Athens, Greece
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.205How to use a DOI?
Abstract

Purpose/Background/Objectives: Aortic stiffness and hemodynamics are established biomarkers for cardiovascular events. Surgical aortic valve replacement (SAVR) remains the first choice of treatment in most patients with aortic stenosis. We investigated the effect of SAVR on aortic stiffness and the role of arterial biomarkers in predicting the echocardiographic respons.

Methods: We included thirty-three patients (mean age 71 ± 8 years, 58% males) with moderate to severe aortic stenosis undergoing SAVR. In measurements prior and acutely after the surgery, carotid-femoral pulse wave velocity (cfPWV) and brachial-ankle pulse wave velocity (baPWV) and aortic hemodynamics (aortic augmentation index corrected for heart rate [AIx@75]) were used as indicators of arterial stiffness. Echocardiography, mean and peak pressure gradient of the aortic valve was measured and their differences post and pre-surgery were calculated (i.e. ΔMeanGradient = MeanGradient post-surgery−MeanGradient pre-surgery).

Results: There was a statistically significant increase on measurements of aortic stiffness (7.5 ± 1.4 vs 8.2 ± 1.9 m/s for cfPWV, p = 0.033) and a decrease in wave reflections (28 ± 13% vs 21 ± 11% for AIx@75, p = 0.015). We also observed a negative association of baseline cfPWV with baseline mean and peak gradient of aortic stenosis (r=−0.598 and r=−0.614 with p = 0.002 and p = 0.001, respectively), independently of age, gender and systolic blood pressure. Baseline cfPWV was associated with ΔMeanGradient and ΔPeakGradient (r = 0.609 and r = 0.533 with p = 0.002 and p = 0.009, respectively). (Figure)

Conclusions: Our study shows that post-operative aortic stiffness increases while there is an improvement of wave reflections. Furthermore, increased aortic stiffness prior to surgery predicts smaller benefit in decreasing transvalvular pressure gradient as assessed echocardiographically, implying that low aortic stiffness prior to surgery could lead to better outcome.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
124 - 124
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.205How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Evangelia Sigala
AU  - Dimitrios Terentes-Printzios
AU  - Charalambos Vlachopoulos
AU  - Konstantinos Triantafillou
AU  - Nikolaos Koumallos
AU  - Andreas Katsaros
AU  - Vasilios Lozos
AU  - Ilias Kouerinis
AU  - Nikolaos Giakis
AU  - Michael Demosthenous
AU  - Konstantinos Filis
AU  - Dimitrios Tousoulis
PY  - 2018
DA  - 2018/12/04
TI  - P152 THE EFFECT OF SURGICAL AORTIC VALVE REPLACEMENT ON AORTIC STIFFNESS AND THE PROGNOSTIC ROLE OF AORTIC STIFFNESS ON SURGICAL SUCCESS
JO  - Artery Research
SP  - 124
EP  - 124
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.205
DO  - 10.1016/j.artres.2018.10.205
ID  - Sigala2018
ER  -