Artery Research

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Volume 24, Issue C, December 2018, Pages 114 - 115

P122 THE ARTERIAL STIFFNESS DYNAMICS UNDER THE EFFECT OF ROSUVASTATIN ADDED TO DIFFERENT COMBINATIONS OF ANTIHYPERTENSIVE DRUGS

Authors
Olga Fedorishina1, Konstantin Protasov2, Anna Torunova2, Nina Scherbakova3, Natalia Petronchak3
1Irkutsk Medical Academy of Continuing Professional Education, Irkutsk, Russia
2"Irkutsk State Medical Academy of Postgraduate Education", 100, Microdistrict Yubileyniy, Irkutsk, 664049, Russia
3Emergency Hospital of the city Angarsk, Angarsk, Russia
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.175How to use a DOI?
Abstract

We studied the influence of rosuvastatin adding to lisinopril/amlodipine or lisinopril/ hydrochlorothiazide fixed combinations on blood pressure (BP) and arterial stiffness dynamics in hypertensive patients of high or very high cardiovascular risk.

Methods: 60 patients (36 men and 24 women aged 52.1 ± 7.3) with uncontrolled high or very high cardiovascular risk hypertension (HTN) were randomized into two groups. Group 1 (n = 30) received a fixed combination of lisinopril/amlodipine 10/5 mg/day. Group 2 consisted of 30 patients who received a fixed combination of lisinopril/hydrochlorothiazide 10-20/12.5 mg/day. The rosuvastatin 20mg/day was added in the both groups. The office BP, central (aortic) BP, augmentation index (AIx), carotid-femoral and carotid-radial pulse wave velocity (PWV) dynamics was evaluated during 24-week follow-up period.

Results: Baseline clinical characteristics did not differ in the groups. The office BP decreased in both groups from 173.3 ± 20.2/104.4 ± 14.0 to 131.2 ± 10.4/83.5 ± 7.8 mmHg (p < 0.001) in the 1-st group and from 168.6 ± 23.6/103.6 ± 15.6 to 135.6 ± 15.1/87.3 ± 11.5 mmHg (p < 0.001) in the 2nd one. The extent of office BP did not differ. Howeverthe degree of central systolic BP reduction was more prominent in the 2nd group (10.5 ± 6,8 and 6.5 ± 7.8 mmHg, respectively). The extent of AIx decline did not differ. Carotid-femoral PWV equally decreased in both groups (from 9.5 ± 1.7 to 8.8 ± 1.8; р = 0.043 and from 8.9 ± 1.2 to 8.1 ± 1.4 m/s; р = 0.001, respectively). Carotid-radial PWV reliably declined only in the 1st group (from 9.5 ± 1.8 to 8.8 ± 1.1 m/s; р = 0.034).

Conclusion: Addition of rosuvastatin to a fixed lisinopril/amlodipine combination has proved to be more effective than lisinopril/hydrochlorothiazide plus rosuvastatin combination in terms of impact on central aortic systolic BP and carotid-radial PWV.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
24 - C
Pages
114 - 115
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.175How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Olga Fedorishina
AU  - Konstantin Protasov
AU  - Anna Torunova
AU  - Nina Scherbakova
AU  - Natalia Petronchak
PY  - 2018
DA  - 2018/12/04
TI  - P122 THE ARTERIAL STIFFNESS DYNAMICS UNDER THE EFFECT OF ROSUVASTATIN ADDED TO DIFFERENT COMBINATIONS OF ANTIHYPERTENSIVE DRUGS
JO  - Artery Research
SP  - 114
EP  - 115
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.175
DO  - 10.1016/j.artres.2018.10.175
ID  - Fedorishina2018
ER  -