Artery Research

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Volume 24, Issue C, December 2018, Pages 113 - 113

P116 CARDIAC OUTPUT IS INCREASED IN YOUNG PEOPLE WITH ELEVATED BP

Authors
Chiara Nardin1, Kaisa Maki-Petaja2, Yasmin Yasmin2, Barry McDonnell3, John R. Cockcroft3, Ian B. Wilkinson2, Carmel M. McEniery2
1Department of Medicine, DIMED, University of Padova, Medicina Interna I^, Ca’ Foncello Hospital, Via Ospedale, 31100, Treviso, Italy
2From Clinical Pharmacology Unit, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK
3Wales Heart Research Institute, Cardiff University, University Hospital, Cardiff, UK
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.169How to use a DOI?
Abstract

Background: The relationship between Blood Pressure (BP) and cardiovascular risk is continuous. Here, we examined haemodynamic characteristics across a range of BP categories, to determine kihaemodynamic mechanisms associated with early elevations of BP and whether these differ by gender.

Methods: 2618 apparently healthy subjects aged 18–40 years were grouped according to gender and BP category, following the recent reclassification of BP as part of AHA/ACC 2017 guidelines. All individuals undertook a lifestyle and medical history questionnaire, together with detailed metabolic and haemodynamic assessments.

Results: Hypertension (HT), stage 1 was the most common BP phenotype in males (29%), whereas normal BP was the most common BP phenotype in females (68%). In both males and females, cardiac output (CO) was significantly increased in subjects with elevated BP and HT versus normotensives (P < 0.001 for all). Stroke volume (SV) was increased in hypertensive males compared with those with elevated or normal BP. In contrast, peripheral vascular resistance (PVR) and pulse wave velocity (PWV) were significantly increased in hypertensive females (P < 0.001 for all) compared with the other BP categories.

Conclusion: In young adults, increased CO is evident at the elevated BP stage and this could represent an initiating mechanism involved in the onset of HT. SV, PVR and PWV might play different roles in females and males in the development of later sustained HT. Elevated CO may be an important risk stratifier for future HT in young people.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
113 - 113
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.169How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Chiara Nardin
AU  - Kaisa Maki-Petaja
AU  - Yasmin Yasmin
AU  - Barry McDonnell
AU  - John R. Cockcroft
AU  - Ian B. Wilkinson
AU  - Carmel M. McEniery
PY  - 2018
DA  - 2018/12/04
TI  - P116 CARDIAC OUTPUT IS INCREASED IN YOUNG PEOPLE WITH ELEVATED BP
JO  - Artery Research
SP  - 113
EP  - 113
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.169
DO  - 10.1016/j.artres.2018.10.169
ID  - Nardin2018
ER  -